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Optical Coherence Tomography signal autocorrelation analysis algorithm applied to blood flow monitoring in mice with Metabolic Syndrome

Grant number: 15/15775-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2016
Effective date (End): October 02, 2019
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Anderson Zanardi de Freitas
Grantee:Lucas Ramos de Pretto
Home Institution: Instituto de Pesquisas Energéticas e Nucleares (IPEN). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:13/26113-6 - Micromachining with ultrashort laser pulses applied to the production and control of optofluidic circuits, AP.TEM
Associated scholarship(s):16/17342-0 - Application of speckle analysis techniques in OCT for optical diagnosis in vivo, BE.EP.DR

Abstract

The Optical Coherence Tomography (OCT) is an interferometry-based diagnostic imaging technique that makes use of non-ionizing electromagnetic radiation. It is characterized as non-invasive, non-contact, high-resolution (few microns) and with good penetration depth (a few millimeters in biological tissues). For these characteristics, it stands out as an attractive technique for biological applications because it does not present risks to patients and does not require prior sample preparation. Furthermore, the OCT technique has a wide variety of analysis aimed to obtain data on underlying flow in samples (such as microcirculation in biological tissues). One of these techniques is based on speckle, type of noise that occurs naturally in the OCT signal. The analysis of speckle intensity fluctuation through time provides data concerning the motion of scatterers and, therefore, concerning sampled flows. One way to analyze the speckle is through its temporal autocorrelation, an approach that will be studied and improved in this project. It will, also, be applied to the monitoring of microcirculation in animal models of metabolic syndrome (MS), a condition that groups several risk factors for cardiovascular disease, diabetes mellitus and hyperglycemia. High blood glucose levels may trigger abnormal responses in the microcirculatory system, which can be observed through speckle analysis in OCT, making the technique an interesting diagnostic tool for MS. In addition, in a collaboration with Prof. James G. Fujimoto from MIT - Massachusetts Institute of Technology. Another technique based on speckle, the OCT Angiography (OCTA) will be studied during the collaboration for 12 months.

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE PRETTO, LUCAS RAMOS; AMARAL, MARCELLO MAGRI; DE FREITAS, ANDERSON ZANARDI; RAELE, MARCUS PAULO. Nondestructive evaluation of fused filament fabrication 3D printed structures using optical coherence tomography. RAPID PROTOTYPING JOURNAL, v. 26, n. 10, p. 1853-1860, NOV 3 2020. Web of Science Citations: 0.
ALIBHAI, A. YASIN; DE PRETTO, LUCAS R.; MOULT, ERIC M.; OR, CHRIS; ARYA, MALVIKA; MCGOWAN, MITCHELL; CARRASCO-ZEVALLOS, OSCAR; LEE, BYUNGKUN; CHEN, SIYU; BAUMAL, CAROLINE R.; WITKIN, ANDRE J.; REICHEL, ELIAS; DE FREITAS, ANDERSON ZANARDI; DUKER, JAY S.; FUJIMOTO, JAMES G.; WAHEED, NADIA K. QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, v. 40, n. 3, p. 412-420, MAR 2020. Web of Science Citations: 9.
DE PRETTO, LUCAS R.; MOULT, ERIC M.; ALIBHAI, A. YASIN; CARRASCO-ZEVALLOS, OSCAR M.; CHEN, SIYU; LEE, BYUNGKUN; WITKIN, ANDRE J.; BAUMAL, CAROLINE R.; REICHEL, ELIAS; DE FREITAS, ANDERSON ZANARDI; DUKER, JAY S.; WAHEED, NADIA K.; FUJIMOTO, JAMES G. Controlling for Artifacts in Widefield Optical Coherence Tomography Angiography Measurements of Non-Perfusion Area. SCIENTIFIC REPORTS, v. 9, JUN 24 2019. Web of Science Citations: 1.
RAELE, MARCUS PAULO; DE PRETTO, LUCAS RAMOS; DE ROSSI, WAGNER; VIEIRA, JR., NILSON DIAS; SAMAD, RICARDO ELGUL. Focus Tracking System for Femtosecond Laser Machining using Low Coherence Interferometry. SCIENTIFIC REPORTS, v. 9, MAR 12 2019. Web of Science Citations: 0.
RAELE, MARCUS PAULO; DE PRETTO, LUCAS RAMOS; ZEZELL, DENISE MARIA. Soldering mask laser removal from printed circuit boards aiming copper recycling. WASTE MANAGEMENT, v. 68, p. 475-481, OCT 2017. Web of Science Citations: 5.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.