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Development of optical coherence tomography (OCT) imaging and signal analysis methodologies for the evaluation of cutaneous angiogenesis

Grant number: 17/21851-0
Support Opportunities:Regular Research Grants
Duration: July 01, 2019 - September 30, 2021
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Marcello Magri Amaral
Grantee:Marcello Magri Amaral
Host Institution: Universidade Brasil. Campus São Paulo. São Paulo , SP, Brazil
Associated researchers:Carla Roberta Tim ; Lívia Assis Garcia


Cutaneous graft is a broadly used on plastic and restorative surgery for treatment of extensive skin lesions caused by burns, abrasions, necrosis of the skin after a trauma or surgery and congenital deformities that underwent surgical corrections. One of the recovery phases of the patient is angiogenesis. The animal model study of cellular and metabolic modulation involved in angiogenesis in skin graft and flap is currently done by laser doppler and invasive histological analysis. These techniques, either by invasiveness or cost issues, make difficult to transfer it to clinical practice. Optical Coherence Tomography (OCT) is a noninvasive technique that uses infrared light to yield microtomographic images of biological structures. The OCT's ability to obtain optical properties of biological tissues has been exploited to develop new diagnostics methods and new OCT signal and imaging analysis techniques, it has been expanding its range of action, especially angiography and spectroscopy OCT. The main goal of this project is to create a research group on Tomography by Optical Coherence in the Universidade Brasil. We propose to develop methodologies for the analysis of OCT images and signals, based on OCT angiography and OCT spectroscopy, applied in angiogenesis of cutaneous grafting. After the project completion, we expect to obtain a OCT methodology that could be transferred to a non-invasive clinical use for angiogenesis progression in dermatology. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE PRETTO, LUCAS RAMOS; AMARAL, MARCELLO MAGRI; DE FREITAS, ANDERSON ZANARDI; RAELE, MARCUS PAULO. Nondestructive evaluation of fused filament fabrication 3D printed structures using optical coherence tomography. RAPID PROTOTYPING JOURNAL, v. 26, n. 10, p. 1853-1860, . (17/21851-0, 15/15775-3, 19/19465-0, 18/20226-7)
DE DEUS, WEVERNILSON F.; DE FRANCA, BRUNA M.; FORERO, JOSUE SEBASTIAN B.; GRANATO, ALESSANDRO E. C.; ULRICH, HENNING; DORIA, ANELISE C. O. C.; AMARAL, MARCELLO M.; SLABON, ADAM; RODRIGUES, BRUNO V. M.. Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties. ACS APPLIED MATERIALS & INTERFACES, v. 13, n. 21, p. 24493-24504, . (17/18826-3, 17/21851-0)
HIDD, SILVIA MARIA CARDOSO MAGALHAES; TIM, CARLA ROBERTA; DUTRA JR, ENEAS DE FREITAS; MARTINS MAIA FILHO, ANTONIO LUIZ; ASSIS, LIVIA; FERREIRA JR, RUI SEABRA; BARRAVIERA, BENEDITO; SILVA, JOSE FIGUEIREDO; AMARAL, MARCELLO MAGRI. Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair. Acta Cirurgica Brasileira, v. 36, n. 4, . (17/21851-0)
AMARAL, MARCELLO MAGRI; DEL-VALLE, MATHEUS; RAELE, MARCUS PAULO; DE PRETTO, LUCAS RAMOS; ANA, PATRICIA APARECIDA. Osteoporosis evaluation through full developed speckle imaging. Journal of Biophotonics, v. 13, n. 7, . (17/21887-4, 17/21851-0)
DE FREITAS DUTRA JUNIOR, ENEAS; HIDD, SILVIA MARIA CARDOSO MAGALHAES; AMARAL, MARCELLO MAGRI; FILHO, ANTONIO LUIZ MARTINS MAIA; ASSIS, LIVIA; FERREIRA, JR., RUI SEABRA; BARRAVIERA, BENEDITO; MARTIGNAGO, CINTIA CRISTINA SANTI; FIGUEREDO-SILVA, JOSE; DE OLIVEIRA, RAUIRYS ALENCAR; et al. Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats. Lasers in Medical Science, . (17/21851-0)

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