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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fibrin biopolymer sealant and aquatic exercise association for calcaneal tendon repair

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Hidd, Silvia Maria Cardoso Magalhaes [1] ; Tim, Carla Roberta [1] ; Dutra Jr, Eneas de Freitas ; Martins Maia Filho, Antonio Luiz [2] ; Assis, Livia [3] ; Ferreira Jr, Rui Seabra ; Barraviera, Benedito [4] ; Silva, Jose Figueiredo [2] ; Amaral, Marcello Magri [3]
Total Authors: 9
[1] Univ Brasil, Sci & Technol Inst, Sao Paulo, SP - Brazil
[2] Univ Estadual Piaui, Ctr Res Biotechnol & Biodivers, Teresina, PI - Brazil
[3] Dutra Jr, Jr., Eneas de Freitas, Univ Brasil, Sci & Technol Inst, Sao Paulo, SP - Brazil
[4] Univ Estadual Paulista, Botucatu Med Sch, Botucatu, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Acta Cirurgica Brasileira; v. 36, n. 4 2021.
Web of Science Citations: 0

ABSTRACT Purpose The aim of this work was to analyze the effect of fibrin biopolymer sealant (FS) associated or not to aquatic exercise (AE) on the calcaneal tendon repair. Methods Forty-four female Wistar rats were randomly divided into four experimental groups: Lesion control (L), Lesion and FS (LS), Lesion and AE (LE) and Lesion and FS associated to AE (LSE). The edema volume (EV), collagen ratio, and histopathological analysis were evaluated after 7, 14, and 21 days of partial tendon transection. Results The EV was statistically reduced for all treatment groups after 7 and 21 days when compared to L group. The LS and LSE had the highest EV reduction after 21 days of treatment. The FS group didn’t induce tissue necrosis or infections on the histopathological analysis. It was observed tenocytes proliferation, granulation tissue and collagen formation in the tendon partial transection area in the FS group. The LSE demonstrated higher amount of granulation tissue and increased the collagen deposition at the injury site. Conclusions Our data suggests that the therapeutic potential of the association of heterologous fibrin biopolymer sealant with aquatic exercise program should be further explored as it may stimulate the regeneration phase and optimize calcaneal tendon recovery. (AU)

FAPESP's process: 17/21851-0 - Development of optical coherence tomography (OCT) imaging and signal analysis methodologies for the evaluation of cutaneous angiogenesis
Grantee:Marcello Magri Amaral
Support Opportunities: Regular Research Grants