Radiotherapy changes salivary properties and impacts quality of life of children with Hodgkin disease

Autor(es)

Marangoni-Lopes, L. ; Rodrigues, L. P. ; Mendonca, R. H. ; Nobre-dos Santos, M.

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 72, p. 99-105, DEC 2016.
• Citações Web of Science: 3

Resumo

Objective: We aimed to perform a longitudinal investigation of the effects of radiotherapy on salivary flow rate, pH, buffering capacity, and protein composition of saliva and on the quality of life of children with Hodgkin disease. Design: Ten children (6-16-year-old) with Hodgkin disease and 10 matched healthy children were investigated. Stimulated and non-stimulated saliva samples were collected at baseline, after 1080 and 2160 cGy of radiation, and 1, 2, and 3 months post-radiotherapy. The salivary flow rate was expressed as mL/min. Buffer capacity was determined by titration. Amylase activity, immunoglobulin A, mucin, and lactoferrin concentrations were determined by ELISA. Quality of life was assessed by Quality of Life Head and Neck module 35 questionnaire. Results: We found that radiotherapy caused hyposalivation at 1080 cGy and 1 month after radiotherapy and reduced buffering capacity at 2160 cGy. Mucin concentration and amylase activity in non-stimulated saliva increased 1 month after radiotherapy. Lactoferrin concentration increased during and after radiotherapy. Immunoglobulin A concentration increased at 1080 cGy, 1 and 2 months, for non stimulated saliva and at 2160 cGy and 1 month for stimulated saliva. Children reported more pain after radiotherapy and more xerostomia during radiotherapy. Conclusion: We concluded that the radiotherapy protocol affected the children's salivary properties and children's quality of life. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/02858-0 - Fluxo salivar, capacidade tampão e composição bioquímica da saliva de crianças do Centro Infantil Boldrini portadoras de linfoma
• Beneficiário: Lenita Marangoni Lopes
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 12/14699-3 - Fluxo salivar, capacidade tampão e composição bioquímica da saliva de crianças e adolescentes com linfoma de Hodgkin
• Beneficiário: Marines Nobre dos Santos Uchôa
• Modalidade de apoio: Auxílio à Pesquisa - Regular