| Texto completo | |
| Autor(es): |
Lemos, George Azevedo
;
Rissi, Renato
;
de Souza Pires, Ivan Luiz
;
de Oliveira, Leticia Prado
;
de Aro, Andrea Aparecida
;
Pimentel, Edson Rosa
;
Palomari, Evanisi Teresa
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Lasers in Medical Science; v. 31, n. 6, p. 1051-1059, AUG 2016. |
| Citações Web of Science: | 10 |
| Resumo | |
The objective of this study was to characterize morphological and biochemistry action of low-level laser therapy (LLLT) on induced arthritis in the temporomandibular joint (TMJ) of rats. Twenty-four male Wistar rats were randomly divided into groups with 12 animals each: (AG) group with arthritis induced in the left TMJ and (LG) group with arthritis induced in the left TMJ and treated with LLLT (830 nm, 30 mW, 3 J/cm(2)). Right TMJs in the AG group were used as noninjected control group (CG). Arthritis was induced by intra-articular injection of 50 mu l Complete Freund's Adjuvant (CFA) and LLLT began 1 week after arthritis induction. Histopathological analysis was performed using sections stained with hematoxylin-eosin, Toluidine Blue, and picrosirius. Biochemical analysis was determined by the total concentration of sulfated glycosaminoglycans (GAGs) and evaluation of matrix metalloproteinases (MMP-2 and MMP-9). Statistical analysis was performed using paired and unpaired t tests, with p < 0.05. Compared to AG, LG had minor histopathological changes in the TMJ, smaller thickness of the articular disc in the anterior (p < 0.0001), middle (p < 0.0001) and posterior regions (p < 0.0001), high birefringence of collagen fibers in the anterior (p < 0.0001), middle (p < 0.0001) and posterior regions (p < 0.0001) on the articular disc, and statistically lower activity of MMP-2 latent (p < 0.0001), MMP-2 active (P = 0.02), MMP-9 latent (p < 0.0001), and MMP-9 active (p < 0.0001). These results suggest that LLLT can increase the remodeling and enhancing tissue repair in TMJ with induced arthritis. (AU) | |
| Processo FAPESP: | 13/21984-9 - Efeito da terapia com o laser de baixa potência e hialuronato de sódio de alto peso molecular na osteoartrite da ATM de ratos induzida por CFA |
| Beneficiário: | Evanisi Teresa Palomari |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |