Electrochemical sensor based on reduced graphene oxide modified with palladium nanoparticles for determination of desipramine in urine samples

Autor(es)

Cincotto, Fernando H. ; Golinelli, Diego L. C. ; Machado, Sergio A. S. ; Moraes, Fernando C.

• Tipo de documento: Artigo Científico
• Fonte: SENSORS AND ACTUATORS B-CHEMICAL; v. 239, p. 488-493, FEB 2017.
• Citações Web of Science: 19

Resumo

A nanostructured material based on palladium nanoparticles supported over reduced graphene has been synthesized, characterised and applied on the sensitivity analysis of antidepressant in urine samples. The morphology, structure, and electrochemical performance of the sensors were characterised by field emission gun scanning electron microscopy, X-ray diffraction, and cyclic voltammetry. The antidepressant quantification process was based on the reversible electrode oxidation of the electrochemically produced desipramine dimer, that appeared as oxidation process at +0.11 V. Differential pulse voltammetry in phosphate buffer solution at pH 7.0 allowed the development of a method to determine desipramine levels in the range of 0.3-2.5 mu mol L-1, with limit of detection (LOD) estimated at 1.04 nmol L-1(0.31 mu g L-1). The system was suitable on the detection of desipramine in urine samples. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/18339-1 - Detecção dos interferentes endócrinos testosterona e estradiol em amostras ambientais empregando eletrodos modificados com grafeno, nanopartículas de ouro e quantum dots.
• Beneficiário: Fernando Henrique Cincotto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
• Beneficiário: Elson Longo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs