Plasma and urine DNA levels are related to microscopic hematuria in patients with bladder urothelial carcinoma

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Pedroso de Almeida, Eduardo Ferreira ; Abdalla, Tomas Elias ; Arrym, Tiago Pedromonico ; Delgado, Pamela de Oliveira ; Wroclawski, Marcelo Langer ; Aguiar Alves, Beatriz da Costa ; Gehrke, Flvia de S. ; Azzalis, Ligia Ajaime ; Alves, Sarah ; Tobias-Machado, Marcos ; de Lima Pompeo, Antonio Carlos ; Affonso Fonseca, Fernando Luiz

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL BIOCHEMISTRY; v. 49, n. 16-17, p. 1274-1277, NOV 2016.
• Citações Web of Science: 5

Resumo

a) Objective: An increase in cell-free DNA was observed in the plasma of many cancer patients. This major biomarker can be used to differentiate patients with malignant neoplasms from those with benign neoplasms or healthy patients. Depending on the characteristic of the tumor, there are qualitative variations in the circulating cell-free DNA. Today, studies on the concentration of fragments of circulating cell-free DNA and their respective sizes in patients with bladder cancer are not plentiful in the literature. A 100% effective plasma tumor marker, which would help in the diagnosis and follow-up of bladder cancer, is yet to be developed; therefore, cell-free DNA levels in the plasma may represent a valuable biomarker for the diagnosis, prognosis and follow-up of patients with this type of tumor. b) Design and methods: In this study we analyze the kinetics of plasma and urine DNA concentrations in patients with bladder cancer, relating them to the other clinical laboratory variables. c) Results: Patients with hematuria showed a positive correlation with urine DNA. d) Conclusion: An increase in plasma and urine DNA was unprecedentedly reported over time, a fact that may come in handy in the prognosis of patients. Furthermore, microscopic haematuria is correlated with plasma and urinary DNA levels. (C) 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/19908-0 - Avaliação das concentrações de DNA plasmático e urinário em pacientes com carcinoma urotelial de bexiga
• Beneficiário: Tomás Elias Abdalla
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica