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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

RP-HPLC x HILIC chromatography for quantifying ertapenem sodium with a look at green chemistry

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Pedroso, Tahisa M. ; Medeiros, Ana C. D. ; Salgado, Herida R. N.
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: Talanta; v. 160, p. 745-753, NOV 1 2016.
Citações Web of Science: 8

Ertapenem sodium is a polar and ionizable compound; therefore, it has little retention on traditional C-18 columns in reverse-phase high-performance liquid chromatography, even using a highly-aqueous mobile phase that can result in dewetting in the stationary phase. Thus, the most coherent process for ERTM is to develop a method for Hydrophilic Interaction Chromatography. However, for the traditional methods in HILIC, the use of a highly organic mobile phase is necessary; usually an amount exceeding 80% acetonitrile is necessary. On the other hand, the RP-HPLC mode is considered for the analysis technique, which is more often used for quantification of substances, and new columns are often introduced to analyze different groups of compounds. Two new analytical methods have been developed for routine analysis. The proposed chromatographic method was adequate and advantageous by presenting simplicity, linearity, precision, accuracy, robustness, detection limits, and satisfactory quantification. Analytical methods are constantly undergoing changes and improvements. Researchers worldwide are rapidly adopting Green Chemistry. The development of new pharmaceutical methods based in Green chemistry has been encouraged by universities and the pharmaceutical industry. Issues related to green chemistry are in evidence and they have been featured in international journals of high impact. The methods described here have economic advantages and they feature an eco-friendly focus, which is discussed in this work. This work was developed with an environmental conscience, always looking to minimize the possible generated organic waste. Therefore, discussion on this aspect is included. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 13/12959-0 - Desenvolvimento e validação de métodos analíticos para caracterização e quantificação de ertapenem sódico em pó liofilizado para solução injetável
Beneficiário:Tahisa Marcela Pedroso
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/03412-3 - Desenvolvimento e validação de um método analítico por cromatografia de interaction Hydrophilic: HILIC amigo do meio ambiente para as análises ao Ertapenem de sódio em pó liofilizado para solução injetável
Beneficiário:Tahisa Marcela Pedroso
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado