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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

RP-HPLC x HILIC chromatography for quantifying ertapenem sodium with a look at green chemistry

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Pedroso, Tahisa M. ; Medeiros, Ana C. D. ; Salgado, Herida R. N.
Total Authors: 3
Document type: Journal article
Source: Talanta; v. 160, p. 745-753, NOV 1 2016.
Web of Science Citations: 8

Ertapenem sodium is a polar and ionizable compound; therefore, it has little retention on traditional C-18 columns in reverse-phase high-performance liquid chromatography, even using a highly-aqueous mobile phase that can result in dewetting in the stationary phase. Thus, the most coherent process for ERTM is to develop a method for Hydrophilic Interaction Chromatography. However, for the traditional methods in HILIC, the use of a highly organic mobile phase is necessary; usually an amount exceeding 80% acetonitrile is necessary. On the other hand, the RP-HPLC mode is considered for the analysis technique, which is more often used for quantification of substances, and new columns are often introduced to analyze different groups of compounds. Two new analytical methods have been developed for routine analysis. The proposed chromatographic method was adequate and advantageous by presenting simplicity, linearity, precision, accuracy, robustness, detection limits, and satisfactory quantification. Analytical methods are constantly undergoing changes and improvements. Researchers worldwide are rapidly adopting Green Chemistry. The development of new pharmaceutical methods based in Green chemistry has been encouraged by universities and the pharmaceutical industry. Issues related to green chemistry are in evidence and they have been featured in international journals of high impact. The methods described here have economic advantages and they feature an eco-friendly focus, which is discussed in this work. This work was developed with an environmental conscience, always looking to minimize the possible generated organic waste. Therefore, discussion on this aspect is included. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/12959-0 - Development and validation of analytical methods for characterization and quantification of Ertapenem sodium in lyophilized powder for injectable solution
Grantee:Tahisa Marcela Pedroso
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/03412-3 - Development and validation of an analytical method by hydrophilic interaction chromatography: HILIC friendly to the environment for analyses to Ertapenem sodium in lyophilized powder for injectable solution
Grantee:Tahisa Marcela Pedroso
Support type: Scholarships abroad - Research Internship - Doctorate