A magneto-motive ultrasound platform designed for pre-clinical and clinical applications

Autor(es)

Diego Ronaldo Thomaz Sampaio ^[1] ; Felipe Wilker Grillo ^[2] ; Alexandre Colello Bruno ^[3] ; Theo Zeferino Pavan ^[4] ; Antonio Adilton Oliveira Carneiro ^[5]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Faculty of Philosophy, Science and Letters of Ribeirão Preto - Brasil

^[2] Universidade de São Paulo. Faculty of Philosophy, Science and Letters of Ribeirão Preto - Brasil

^[3] Universidade de São Paulo. Faculty of Philosophy, Science and Letters of Ribeirão Preto - Brasil

^[4] Universidade de São Paulo. Faculty of Philosophy, Science and Letters of Ribeirão Preto - Brasil

^[5] Universidade de São Paulo. Faculty of Philosophy, Science and Letters of Ribeirão Preto - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Res. Biomed. Eng.; v. 32, n. 4, p. 337-346, 2017-01-12.

Resumo

Abstract Introduction Magneto-motive ultrasound (MMUS) combines magnetism and ultrasound (US) to detect magnetic nanoparticles in soft tissues. One type of MMUS called shear-wave dispersion magneto-motive ultrasound (SDMMUS) analyzes magnetically induced shear waves (SW) to quantify the elasticity and viscosity of the medium. The lack of an established presets or protocols for pre-clinical and clinical studies currently limits the use of MMUS techniques in the clinical setting. Methods This paper proposes a platform to acquire, process, and analyze MMUS and SDMMUS data integrated with a clinical ultrasound equipment. For this purpose, we developed an easy-to-use graphical user interface, written in C++/Qt4, to create an MMUS pulse sequence and collect the ultrasonic data. We designed a graphic interface written in MATLAB to process, display, and analyze the MMUS images. To exemplify how useful the platform is, we conducted two experiments, namely (i) MMUS imaging to detect magnetic particles in the stomach of a rat, and (ii) SDMMUS to estimate the viscoelasticity of a tissue-mimicking phantom containing a spherical target of ferrite. Results The developed software proved to be an easy-to-use platform to automate the acquisition of MMUS/SDMMUS data and image processing. In an in vivo experiment, the MMUS technique detected an area of 6.32 ± 1.32 mm2 where magnetic particles were heterogeneously distributed in the stomach of the rat. The SDMMUS method gave elasticity and viscosity values of 5.05 ± 0.18 kPa and 2.01 ± 0.09 Pa.s, respectively, for a tissue-mimicking phantom. Conclusion Implementation of an MMUS platform with addressed presets and protocols provides a step toward the clinical implementation of MMUS imaging equipment. This platform may help to localize magnetic particles and quantify the elasticity and viscosity of soft tissues, paving a way for its use in pre-clinical and clinical studies. (AU)

• Processo FAPESP: 10/07639-9 - Motilidade gastrintestinal: investigações clínicas, fisiopatológicas e biofarmacêuticas
• Beneficiário: Ricardo Brandt de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/18854-6 - Imagens fotoacústicas e ultrassônicas para caracterização de tecidos viscoelásticos
• Beneficiário: Theo Zeferino Pavan
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/18420-3 - Implementação da técnica de magneto-acustografia em um equipamento de ultrassom por imagem
• Beneficiário: Diego Ronaldo Thomaz Sampaio
• Modalidade de apoio: Bolsas no Brasil - Mestrado