The telomere attrition rate is not accelerated in women born small for gestational age: A birth cohort study

Autor(es)

de Melo, Anderson Sanches ; dos Reis, Rosana Maria ; Calado, Rodrigo T. ; Cavalli, Ricardo de Carvalho ; Bettiol, Heloisa ; Cardoso, Viviane Cunha ; Ferriani, Rui Alberto ; Barbieri, Marco Antonio ; Vieira, Carolina Sales

• Tipo de documento: Artigo Científico
• Fonte: Gene; v. 600, p. 16-20, FEB 5 2017.
• Citações Web of Science: 2

Resumo

Background: Physiologically, a reduction in telomere length (LTL) occurs with aging, but epigenetic changes may accelerate telomere shortening and also facilitate the onset of oxidative/inflammatory stress and the development of clinical/metabolic comorbidities in life spam. Although individuals born small for gestational age (SGA) may be related to those epigenetic changes, the assessment of LTL in individuals born SGA has yielded conflicting results (only cross-sectional studies) and has not been carried out in longitudinal studies. We performed a birth cohort study to evaluate the rate of telomere erosion in women born SGA in comparison to women born appropriate for gestational age (AGA) assessed at two different time points during the third decade of life. In our research, born SGA or AGA showed no difference in LTL shortening during a period of five years in the third decade of life. Our finding may have implications for understanding the natural history of diseases in lifespan because the same women (under the influence of similar environmental factors) may be accessed in different phases of life. Thus, the analysis of the present cohort population at a more advanced age may reveal a dynamics of telomere shortening different from here and its possible relation with onset of age-related diseases. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 00/09508-7 - Da saúde perinatal à saúde do adulto jovem: estudo da coorte nascida em 1978/79 nos hospitais de Ribeirão Preto, SP
• Beneficiário: Marco Antonio Barbieri
• Modalidade de apoio: Auxílio à Pesquisa - Temático