Dosimetric study of photobiomodulation therapy in 5-FU-induced oral mucositis in hamsters

Autor(es)

Cotomacio, Claudia Carrara ; Campos, Luana ; de Souza, Douglas Nesadal ; Arana-Chavez, Victor Elias ; Simoes, Alyne

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biomedical Optics; v. 22, n. 1 JAN 2017.
• Citações Web of Science: 2

Resumo

Oral mucositis (OM) is a debilitating consequence of cancer treatment that could be treated with photobiomodulation therapy (PBMT); however, there is no consensus about its dosimetric parameters for OM healing. The aim of this study was to compare different PBMT protocols on OM treatment, through clinical and histological analysis. Thirty hamsters were used, in an induced model of OM by 5-fluorouracil (5-FU) and superficial scratching, in seven days of follow-up. The animals were divided into five groups: control (C), which received only anesthesia and chemotherapeutic vehicle; chemotherapy (Ch), which received anesthesia, 5-FU, and scratches; laser 1 (L1), the same as Ch group, PBMT 6 J/cm(2) and 0.24 J (one point); laser 2 (L2), the same as Ch group, PBMT 25 J/cm2 and 1 J (one point); and laser 3 (L3), the same as Ch group, PBMT 4 points of 0.24 J and 6 J/cm(2) each. The laser used has. lambda = 660 nm, 0.04 cm(2) of spot area, and 40 mW. The best PBMT protocol to maintain lowest OM levels compared to Ch group was L1, followed by L2 and L3. Our results suggest that the application mode of PBMT and the energy delivered per area could interfere with the OM healing. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

• Processo FAPESP: 11/14013-1 - Estudo bioquímico e histológico comparativo do efeito das fototerapias LED, laser de baixa ou alta potência na mucosite oral e do laser na hipofunção das glândulas salivares em hamsters tratados com 5-fluorouracil
• Beneficiário: Alyne Simões Gonçalves
• Modalidade de apoio: Auxílio à Pesquisa - Regular