Vasodilators in Septic Shock Resuscitation: A Clinical Perspective

Autor(es)

Correa, Thiago Domingos ; Rabello Filho, Roberto ; Cesar Assuncao, Murillo Santucci ; Silva, Eliezer ; Lima, Alexandre

• Tipo de documento: Artigo de Revisão
• Fonte: Shock; v. 47, n. 3, p. 269-275, MAR 2017.
• Citações Web of Science: 4

Resumo

Microcirculatory abnormalities have been shown to be frequent in patients with septic shock despite normalization of systemic hemodynamics. Several studies have explored the impact of vasodilator therapy (prostacyclin, inhaled nitric oxide, topic acetylcholine, and nitroglycerin) on microcirculation and tissue perfusion, with contradictory findings.In this narrative review, we briefly present the pathophysiological aspects of microcirculatory dysfunction, and depict the evidence supporting the use of vasodilators and other therapeutic interventions (fluid administration, blood transfusion, vasopressors, and dobutamine) aiming to improve the microcirculatory flow in septic shock patients. (AU)

• Processo FAPESP: 14/11120-0 - Efeito do tratamento com nitroglicerina na microcirculação de pacientes com choque séptico
• Beneficiário: Eliezer Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular