Vasodilators in Septic Shock Resuscitation: A Clinical Perspective

Correa, Thiago Domingos; Rabello Filho, Roberto; Cesar Assuncao, Murillo Santucci; Silva, Eliezer; Lima, Alexandre

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Vasodilators in Septic Shock Resuscitation: A Clinical Perspective

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Author(s):	Correa, Thiago Domingos ; Rabello Filho, Roberto ; Cesar Assuncao, Murillo Santucci ; Silva, Eliezer ; Lima, Alexandre Total Authors: 5
Document type:	Review article
Source:	Shock; v. 47, n. 3, p. 269-275, MAR 2017.
Web of Science Citations:	4
Abstract
Microcirculatory abnormalities have been shown to be frequent in patients with septic shock despite normalization of systemic hemodynamics. Several studies have explored the impact of vasodilator therapy (prostacyclin, inhaled nitric oxide, topic acetylcholine, and nitroglycerin) on microcirculation and tissue perfusion, with contradictory findings.In this narrative review, we briefly present the pathophysiological aspects of microcirculatory dysfunction, and depict the evidence supporting the use of vasodilators and other therapeutic interventions (fluid administration, blood transfusion, vasopressors, and dobutamine) aiming to improve the microcirculatory flow in septic shock patients. (AU)

FAPESP's process:	14/11120-0 - Vasodilatory therapy with nitroglyceryn in patients with septic shock
Grantee:	Eliezer Silva
Support Opportunities:	Regular Research Grants

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