Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols

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da Rocha, Claudia Quintino ; de-Faria, Felipe Meira ; Marcourt, Laurence ; Ebrahimi, Samad Nejad ; Kitano, Bruna Tiemi ; Ghilardi, Amanda Franceschini ; Ferreira, Anderson Luiz ; de Almeida, Ana Cristina Alves ; Dunder, Ricardo Jose ; Monteiro Souza-Brito, Alba Regina ; Hamburger, Matthias ; Vilegas, Wagner ; Queiroz, Emerson Ferreira ; Wolfender, Jean-Luc

• Tipo de documento: Artigo Científico
• Fonte: Phytochemistry; v. 135, p. 93-105, MAR 2017.
• Citações Web of Science: 12

Resumo

The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian me-dicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, gluta-thione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenyl-ethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/01868-1 - Avaliação de atividade gastroprotetora do extrato hidro-alcoólico (70%) obtido a partir das raízes de Arrabidaea brachypoda (DC.) Bureau
• Beneficiário: Amanda Franceschini Ghilardi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 14/03728-8 - Arrabidaea spp: estudos para viabilizar o desenvolvimento de fitomedicamentos
• Beneficiário: Cláudia Quintino da Rocha
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 09/52237-9 - Fitoterápicos padronizados como alvo para o tratamento de doenças crônicas
• Beneficiário: Wagner Vilegas
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático