Gastroprotective effects of hydroethanolic root extract of Arrabidaea brachypoda: Evidences of cytoprotection and isolation of unusual glycosylated polyphenols

Author(s):Show less -

da Rocha, Claudia Quintino ; de-Faria, Felipe Meira ; Marcourt, Laurence ; Ebrahimi, Samad Nejad ; Kitano, Bruna Tiemi ; Ghilardi, Amanda Franceschini ; Ferreira, Anderson Luiz ; de Almeida, Ana Cristina Alves ; Dunder, Ricardo Jose ; Monteiro Souza-Brito, Alba Regina ; Hamburger, Matthias ; Vilegas, Wagner ; Queiroz, Emerson Ferreira ; Wolfender, Jean-Luc

• Document type: Journal article
• Source: Phytochemistry; v. 135, p. 93-105, MAR 2017.
• Web of Science Citations: 12

Abstract

The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian me-dicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, gluta-thione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenyl-ethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 12/01868-1 - Evaluation of the gastroprotective activity of the hydro-alcoholic extract (70%) obtained from the roots of Arrabidaea brachypoda (DC.) Bureau
• Grantee: Amanda Franceschini Ghilardi
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 14/03728-8 - Arrabidaea spp: studies to make possible the development of phytomedicines
• Grantee: Cláudia Quintino da Rocha
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases
• Grantee: Wagner Vilegas
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants