Expression of HLA-E molecules in the placental tissue of women infected with HIV-1 and uninfected women

Autor(es)

Martinez, Juliana ; Santiago, Mariana Rodrigues ; Martelli-Palomino, Gustavo ; de Souza, Diego Agra ; Alves Silva, Tarsia Giabardo ; Barros Silva, Gyl Eanes ; Chahud, Fernando ; Donadi, Eduardo Antonio ; Morais Fernandes, Ana Paula

• Tipo de documento: Artigo Científico
• Fonte: Placenta; v. 49, p. 33-36, JAN 2017.
• Citações Web of Science: 0

Resumo

Introduction: Expression of HLA-E molecule in the placental extravillous trophoblast is associated with immune system cell inhibition, resulting in immune tolerance to fetus during pregnancy. HIV-1 can infect trophoblast cells and modify the expression of HLA-E, which may inhibit the cytotoxic activity of the immune system. Aim: The aim of this study was to evaluate HLA-E expression in third trimester placental tissue of women infected with HIV-1 and uninfected women. Methods: We performed an immunohistochemistry assay to evaluate HLA-E staining in the placental tissue of 99 HIV-1 infected and 85 uninfected women. A pathologist analyzed and classified the HLA-E expression in the placental cells. Results: Irrespective of the HIV status, HLA-E staining was observed in the extravillous trophoblast cells, endothelial cells and Hofbauer cells, but not in the syncytiotrophoblast. HLA-E staining showed no significant difference between the placental tissue of women infected with HIV-1 and uninfected women (P = 0.76). Considering HIV-1 infected women, HLA-E staining was not influenced by HIV-1 viral load (P = 0.48), CD4(+) T-cell count (P = 0.10) and antiretroviral therapy used during pregnancy (P = 0.54). Discussion: Despite the presence of HIV-1 infection, the expression of HLA-E molecules in the placental tissue was not modified when the infection was under antiretroviral therapy control. (C) 2016 Published by Elsevier Ltd. (AU)

• Processo FAPESP: 11/16885-6 - Expressão das moléculas HLA-E em tecidos placentários de mulheres portadoras ou não do HIV-1
• Beneficiário: Juliana Martinez
• Modalidade de apoio: Bolsas no Brasil - Mestrado