Refractory and/or Relapsing Cryptococcosis Associated with Acquired Immune Deficiency Syndrome: Clinical Features, Genotype, and Virulence Factors of Cryptococcus spp. Isolates

Autor(es)

Nascimento, Erika ; Vitali, Lucia H. ; Tonani, Ludmilla ; Von Zeska Kress, Marcia R. ; Takayanagui, Osvaldo M. ; Martinez, Roberto

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Tropical Medicine and Hygiene; v. 94, n. 5, p. 975-981, 2016.
• Citações Web of Science: 3

Resumo

Refractory and relapsing crytocococcosis in acquired immune deficiency syndrome (AIDS) patients have a poor prognosis. The risk factors for this complicated infection course were evaluated by comparing refractory and/or relapsing cryptococcosis in human immunodeficiency virus-coinfected patients (cohort 1) with another group of AIDS patients who adequately responded to antifungals (cohort 2). Except for one isolate of Cryptococcus gattii from a cohort 2 case, all other isolates were identified as Cryptococcus neoformans var. grubii, sex type a, genotype VNI, including Cryptococcus reisolated from the relapse or in the refractory state. No differences were observed with respect to Cryptococcus capsule size and in the melanin and phospholipase production. The cohort 1 patients presented higher prevalence of cryptococcemia, cerebral dissemination, chronic liver disease, and leucopenia, and have increased death rate. Apparently, the refractory and/or relapsing cryptococcosis in the AIDS patients were more related to the host and the extent of the infection than to the fungal characteristics. (AU)

• Processo FAPESP: 10/51932-2 - Comparacao fenotipica e genotipica de cryptococcus isolados de pacientes com diferentes aspectos clinicos da infeccao fungica
• Beneficiário: Érika Nascimento
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado