Quercetin loaded particles production by means of supercritical fluid extraction of emulsions: Process scale-upstudy and thermo-economic evaluation

Autor(es)

Levai, Gyorgy ; Albarelli, Juliana Q. ; Santos, Diego T. ; Meireles, M. Angela A. ; Martin, Angel ; Rodriguez-Rojo, Soraya ; Jose Cocero, Maria

• Tipo de documento: Artigo Científico
• Fonte: FOOD AND BIOPRODUCTS PROCESSING; v. 103, p. 27-38, MAY 2017.
• Citações Web of Science: 7

Resumo

Quercetin is an antioxidant compound with promising activity against a wide variety of diseases. However, a major limitation for the clinical application of quercetin is its low bioavailability, due to its low solubility in water. One way to increase the bioavailability of quercetin is to precipitate it in sub-micrometricscale, encapsulated by a surfactant material, using the Supercritical Fluid Extraction of Emulsions (SFEE) method. The objective of this work is to study the scale-up of a semi-continuous SFEE process for the production of microencapsulated quercetin. An experimental study of the encapsulation of quercetin in soy-bean lecithin-Pluronic L64 degrees surfactants was performed in order to evaluate the variation of product characteristics with significant parameters, such as duration of SFEE, density of CO2 medium, used CO2/L of emulsion (kg/L), and thus determine the suitable conditions for scale-up. In addition, a themo-economic evaluation was done in order to identify bottlenecks during scale-up and promote solutions. According to the thermo-economic evaluation, the decrease of CO2 flow demonstrated to be the main parameter to decrease the energy demand and cost of manufacturing of the SFEE process. Thus further experimental studies should be done towards optimization of this parameter. (C) 2017 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/18114-2 - Aproveitamento integral de biomassas utilizando fluidos sub/supercríticos: avaliação de cenários tecnológicos sob ópticas ambiental, energética e econômica
• Beneficiário: Juliana Queiroz Albarelli
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/06954-1 - Desenvolvimento de uma biorrefinaria sub/supercrítica integrada, energeticamente autossuficiente e economicamente viável com a ajuda de modelagem e simulação computacional
• Beneficiário: Juliana Queiroz Albarelli
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado