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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Quercetin loaded particles production by means of supercritical fluid extraction of emulsions: Process scale-upstudy and thermo-economic evaluation

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Author(s):
Levai, Gyorgy ; Albarelli, Juliana Q. ; Santos, Diego T. ; Meireles, M. Angela A. ; Martin, Angel ; Rodriguez-Rojo, Soraya ; Jose Cocero, Maria
Total Authors: 7
Document type: Journal article
Source: FOOD AND BIOPRODUCTS PROCESSING; v. 103, p. 27-38, MAY 2017.
Web of Science Citations: 7
Abstract

Quercetin is an antioxidant compound with promising activity against a wide variety of diseases. However, a major limitation for the clinical application of quercetin is its low bioavailability, due to its low solubility in water. One way to increase the bioavailability of quercetin is to precipitate it in sub-micrometricscale, encapsulated by a surfactant material, using the Supercritical Fluid Extraction of Emulsions (SFEE) method. The objective of this work is to study the scale-up of a semi-continuous SFEE process for the production of microencapsulated quercetin. An experimental study of the encapsulation of quercetin in soy-bean lecithin-Pluronic L64 degrees surfactants was performed in order to evaluate the variation of product characteristics with significant parameters, such as duration of SFEE, density of CO2 medium, used CO2/L of emulsion (kg/L), and thus determine the suitable conditions for scale-up. In addition, a themo-economic evaluation was done in order to identify bottlenecks during scale-up and promote solutions. According to the thermo-economic evaluation, the decrease of CO2 flow demonstrated to be the main parameter to decrease the energy demand and cost of manufacturing of the SFEE process. Thus further experimental studies should be done towards optimization of this parameter. (C) 2017 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/18114-2 - Integral utilization of biomasses using sub/supercritical fluids: environmental, energetic and economic assessment of technological scenarios
Grantee:Juliana Queiroz Albarelli
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/06954-1 - Development of an energetic self-sufficient and economically viable integrated sub/supercritical fluid-based biorefinery by the aid of computational modeling and simulation
Grantee:Juliana Queiroz Albarelli
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor