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Combination and coupling of processes for the production and encapsulation of value-added vegetal extracts: technical and economic evaluation

Abstract

The production of value-added plant extracts is an area that is increasing annually due to increasing evidence that certain phytochemicals can be used for the prevention and treatment of certain diseases. However, the industry still uses outdated processes and inefficient techniques. This research project objective is to develop advanced processes for the production of value-added plant extracts based on the combination/coupling techniques and procedures for annatto, jabuticaba residue, and Brazilian ginseng because of their chemical compositions and functional properties. The process will be developed based on the use of ultrasound and/or microwave as a pretreatment. A combination of supercritical fluid extraction, pressurized liquid and ultrasound for the extraction of bioactive compounds from the raw material, the solid phase extraction for the on-line purification of the crude extract obtained and SAS (Supercritical Antisolvent process) or SFEE (Supercritical fluid extraction from emulsion process), also in line, to eliminate the organic solvent and formation of micro / nano particles encapsulated or not. The coupling of chromatographic techniques (SPE and HPLC ) to the existing ultrasound-assisted supercritical fluid/pressurized liquid extraction system and to a formation particle system, which will be assembled. The effects of different process conditions on production cost will be evaluated. The economic analysis of the developed processes will be carried out using the simulator SuperPro Designer®. The biofunctional vegetal extracts produced using the developed procedures can be used as an ingredient in the manufacture of a variety of food products, cosmetics, etc. This study aims to confirm the economic feasibility of combining / coupling processes in the production of value-added plant extracts for use in foods, drugs, among others, and training highly qualified human resources in this field. (AU)

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Scientific publications (44)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, ERIC KEVEN; ROSA, M. THEREZA M. G.; MEIRELES, M. ANGELA A.. Ultrasound-assisted formation of emulsions stabilized by biopolymers. CURRENT OPINION IN FOOD SCIENCE, v. 5, p. 50-59, . (12/10685-8)
ALCAZAR-ALAY, SYLVIA CAROLINA; ALMEIDA MEIRELES, MARIA ANGELA. Physicochemical properties, modifications and applications of starches from different botanical sources. FOOD SCIENCE AND TECHNOLOGY, v. 35, n. 2, p. 215-236, . (12/10685-8)
ZABOT, GIOVANI L.; SILVA, ERIC KEVEN; AZEVEDO, VIVIANE M.; MEIRELES, M. ANGELA A.. Replacing modified starch by inulin as prebiotic encapsulant matrix of lipophilic bioactive compounds. Food Research International, v. 85, p. 26-35, . (12/10685-8, 14/15685-1, 15/22226-6, 15/13299-0)
SILVA, ERIC KEVEN; AZEVEDO, VIVIANE M.; CUNHA, ROSIANE L.; HUBINGER, MIRIAM D.; MEIRELES, M. ANGELA A.. Ultrasound-assisted encapsulation of annatto seed oil: Whey protein isolate versus modified starch. FOOD HYDROCOLLOIDS, v. 56, p. 71-83, . (12/10685-8)
BORGES, ENDLER M.; ROSTAGNO, MAURICIO A.; MEIRELES, M. ANGELA A.. Sub-2 mu m fully porous and partially porous (core-shell) stationary phases for reversed phase liquid chromatography. RSC ADVANCES, v. 4, n. 44, p. 22875-22887, . (11/07466-0, 12/10685-8, 13/04304-4, 13/15049-5)
ZABOT, GIOVANI L.; MEIRELES, M. ANGELA A.. On-line process for pressurized ethanol extraction of onion peels extract and particle formation using supercritical antisolvent. JOURNAL OF SUPERCRITICAL FLUIDS, v. 110, p. 230-239, . (12/10685-8, 15/13299-0)
CARVALHO, PEDRO I. N.; FELIPE OSORIO-TOBON, J.; ROSTAGNO, MAURICIO A.; PETENATE, ADEMIR J.; MEIRELES, M. ANGELA A.. Techno-economic evaluation of the extraction of turmeric (Curcuma longa L.) oil and ar-turmerone using supercritical carbon dioxide. JOURNAL OF SUPERCRITICAL FLUIDS, v. 105, n. SI, p. 44-54, . (13/04304-4, 12/10685-8, 13/20758-5)
OSORIO-TOBON, J. FELIPE; CARVALHO, PEDRO I. N.; ROSTAGNO, MAURICIO A.; PETENATE, ADEMIR J.; MEIRELES, M. ANGELA A.. Extraction of curcuminoids from deflavored turmeric (Curcuma longa L.) using pressurized liquids: Process integration and economic evaluation. JOURNAL OF SUPERCRITICAL FLUIDS, v. 95, p. 167-174, . (13/04304-4, 12/10685-8)
MORAES, MOYSES N.; ZABOT, GIOVANI L.; MEIRELES, M. ANGELA A.. Extraction of tocotrienols from annatto seeds by a pseudo continuously operated SFE process integrated with low-pressure solvent extraction for bixin production. JOURNAL OF SUPERCRITICAL FLUIDS, v. 96, n. SI, p. 262-271, . (12/10685-8)
SILVA, ERIC KEVEN; THEREZA, M.; GOMES, M. S.; HUBINGER, MIRIAM DUPAS; CUNHA, ROSIANE LOPES; ANGELA, M.; MEIRELES, A.. Ultrasound-assisted formation of annatto seed oil emulsions stabilized by biopolymers. FOOD HYDROCOLLOIDS, v. 47, p. 1-13, . (12/10685-8)
CARDENAS-TORO, FIORELLA P.; ALCAZAR-ALAY, SYLVIA C.; COUTINHO, JANCLEI P.; GODOY, HELENA TEIXEIRA; FORSTER-CARNEIRO, TANIA; MEIRELES, M. ANGELA A.. Pressurized liquid extraction and low-pressure solvent extraction of carotenoids from pressed palm fiber: Experimental and economical evaluation. FOOD AND BIOPRODUCTS PROCESSING, v. 94, p. 90-100, . (12/10685-8, 11/19817-1)
ZABOT, GIOVANI L.; MORAES, MOYSES N.; ROSTAGNO, MAURICIO A.; MEIRELES, M. ANGELA A.. Fast analysis of phenolic terpenes by high-performance liquid chromatography using a fused-core column. ANALYTICAL METHODS, v. 6, n. 18, p. 7457-7468, . (13/04304-4, 12/10685-8, 13/15049-5)
ALBARELLI, JULIANA Q.; SANTOS, DIEGO T.; JOSE COCERO, MARIA; MEIRELES, M. ANGELA A.. Economic Analysis of an Integrated Annatto Seeds-Sugarcane Biorefinery Using Supercritical CO2 Extraction as a First Step. MATERIALS, v. 9, n. 6, . (15/06954-1, 13/18114-2, 12/10685-8, 15/13299-0)
ZABOT, GIOVANI L.; MORAES, MOYSES N.; CARVALHO, PEDRO I. N.; MEIRELES, M. ANGELA A.. New proposal for extracting rosemary compounds: Process intensification and economic evaluation. INDUSTRIAL CROPS AND PRODUCTS, v. 77, p. 758-771, . (12/10685-8, 11/23665-2)
FELIPE OSORIO-TOBON, J.; CARVALHO, PEDRO I. N.; ROSTAGNO, MAURICIO A.; PETENATE, ADEMIR J.; MEIRELES, M. ANGELA A.. Precipitation of curcuminoids from an ethanolic turmeric extract using a supercritical antisolvent process. JOURNAL OF SUPERCRITICAL FLUIDS, v. 108, p. 26-34, . (13/04304-4, 12/10685-8)
SILVA, ERIC KEVEN; ZABOT, GIOVANI L.; MEIRELES, M. ANGELA A.. Ultrasound-assisted encapsulation of annatto seed oil: Retention and release of a bioactive compound with functional activities. Food Research International, v. 78, p. 159-168, . (12/10685-8, 14/15685-1)
SANTOS, DIEGO T.; ALBARELLI, JULIANA Q.; ROSTAGNO, MAURICIO A.; ENSINAS, ADRIANO V.; MARECHAL, FRANCOIS; MEIRELES, M. ANGELA A.. New proposal for production of bioactive compounds by supercritical technology integrated to a sugarcane biorefinery. Clean Technologies and Environmental Policy, v. 16, n. 7, SI, p. 1455-1468, . (13/15049-5, 10/16485-5, 12/19304-7, 12/10685-8, 09/17234-9)
CARVALHO, PEDRO I. N.; OSORIO-TOBON, JUAN F.; ZABOT, GIOVANI L.; MEIRELES, M. ANGELA A.. Spatial and temporal temperature distributions in fixed beds undergoing supercritical fluid extraction. INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES, v. 47, p. 504-516, . (12/10685-8, 15/13299-0, 13/04304-4, 13/20758-5)
ALBARELLI, J. Q.; MIAN, A.; SANTOS, D. T.; ENSINAS, A. V.; MARECHAL, F.; MEIRELES, M. A. A.. MULTI-OBJECTIVE OPTIMIZATION OF SUPERCRITICAL WATER GASIFICATION OF LEFTOVER BRAZILIAN GINSENG ROOTS AFTER PHYTOCHEMICAL RECOVERY STEPS. Brazilian Journal of Chemical Engineering, v. 34, n. 3, p. 841-850, . (12/19304-7, 12/10685-8, 15/06954-1, 10/16485-5, 09/17234-9, 13/18114-2)
ALBARELLI, JULIANA Q.; SANTOS, DIEGO T.; ENSINAS, ADRIANO V.; MARECHAL, FRANCOIS; MATO, FIDEL A.; COCERO, MARIA J.; MEIRELES, M. ANGELA A.. Thermo-economic and environmental comparison of supercritical water and enzymatic hydrolysis of sugarcane bagasse in a biorefinery concept. ENERGY, v. 141, p. 139-148, . (15/06954-1, 13/18114-2, 12/10685-8, 15/13299-0)
SILVA, ERIC KEVEN; ZABOT, GIOVANI L.; BARGAS, MATHEUS A.; MEIRELES, M. ANGELA A.. Microencapsulation of lipophilic bioactive compounds using prebiotic carbohydrates: Effect of the degree of inulin polymerization. Carbohydrate Polymers, v. 152, p. 775-783, . (15/22226-6, 15/13299-0, 14/15685-1, 12/10685-8)
SANTANA, ADINA L.; ALBARELLI, JULIANA Q.; SANTOS, DIEGO T.; SOUZA, RENATO; MACHADO, NELIO T.; ARAUJO, MARILENA E.; MEIRELES, M. ANGELA A.. Kinetic behavior, mathematical modeling, and economic evaluation of extracts obtained by supercritical fluid extraction from defatted assai waste. FOOD AND BIOPRODUCTS PROCESSING, v. 107, p. 25-35, . (15/13299-0, 15/06954-1, 13/18114-2, 12/10685-8)
ALCAZAR-ALAY, SYLVIA C.; FELIPE OSORIO-TOBON, J.; FORSTER-CARNEIRO, TANIA; STEEL, CAROLINE J.; MEIRELES, M. ANGELA A.. Polymer modification from semi-defatted annatto seeds using hot pressurized water and supercritical CO2. JOURNAL OF SUPERCRITICAL FLUIDS, v. 129, n. SI, p. 48-55, . (12/10685-8)
ROSA, M. THEREZA M. G.; SILVA, ERIC KEVEN; SANTOS, DIEGO T.; PETENATE, ADEMIR J.; MEIRELES, M. ANGELA A.. Obtaining annatto seed oil miniemulsions by ultrasonication using aqueous extract from Brazilian ginseng roots as a biosurfactant. Journal of Food Engineering, v. 168, p. 68-78, . (12/10685-8, 10/16485-5, 09/17234-9, 12/19304-7)
FELIPE OSORIO-TOBON, J.; CARVALHO, PEDRO I. N.; ROSTAGNO, MAURICIO A.; MEIRELES, M. ANGELA A.. Process integration for turmeric products extraction using supercritical fluids and pressurized liquids: Economic evaluation. FOOD AND BIOPRODUCTS PROCESSING, v. 98, p. 227-235, . (13/04304-4, 12/10685-8)
RODRIGUES, LIARA M.; ALCAZAR-ALAY, SYLVIA C.; PETENATE, ADEMIR J.; MEIRELES, MARIA ANGELA A.. Bixin extraction from defatted annatto seeds. COMPTES RENDUS CHIMIE, v. 17, n. 3, p. 268-283, . (12/10685-8, 09/17234-9)
ROSTAGNO, MAURICIO A.; DEBIEN, ISABEL C. N.; VARDANEGA, RENATA; NOGUEIRA, GISLAINE C.; BARBERO, GERARDO F.; MEIRELES, M. ANGELA A.. Fast analysis of beta-ecdysone in Brazilian ginseng (Pfaffia glomerata) extracts by high-performance liquid chromatography using a fused-core column. ANALYTICAL METHODS, v. 6, n. 8, p. 2452-2459, . (13/04304-4, 12/10685-8, 13/15049-5)
SANTOS, DIEGO TRESINARI; DE ALMEIDA MEIRELES, MARIA ANGELA. Developing novel one-step processes for obtaining food-grade O/W emulsions from pressurized fluid extracts: processes description, state of the art and perspectives. FOOD SCIENCE AND TECHNOLOGY, v. 35, n. 4, p. 579-587, . (12/10685-8, 12/19304-7, 10/16485-5, 09/17234-9)
CARDENAS-TORO, FIORELLA P.; FORSTER-CARNEIRO, TANIA; ROSTAGNO, MAURICIO A.; PETENATE, ADEMIR. J.; MAUGERI FILHO, FRANCISCO; MEIRELES, M. ANGELA A.. Integrated supercritical fluid extraction and subcritical water hydrolysis for the recovery of bioactive compounds from pressed palm fiber. JOURNAL OF SUPERCRITICAL FLUIDS, v. 93, n. SI, p. 42-48, . (12/10685-8, 11/19817-1)
ZABOT, GIOVANI L.; MORAES, MOYSES N.; MEIRELES, M. ANGELA A.. Influence of the bed geometry on the kinetics of rosemary compounds extraction with supercritical CO2. JOURNAL OF SUPERCRITICAL FLUIDS, v. 94, p. 234-244, . (12/10685-8)
FELIPE OSORIO-TOBON, J.; CARVALHO, PEDRO I. N.; FERNANDEZ BARBERO, GERARDO; NOGUEIRA, GISLAINE CHRYSTINA; ROSTAGNO, MAURICIO ARIEL; DE ALMEIDA MEIRELES, MARIA ANGELA. Fast analysis of curcuminoids from turmeric (Curcuma longa L.) by high-performance liquid chromatography using a fused-core column. Food Chemistry, v. 200, p. 167-174, . (13/04304-4, 12/10685-8, 13/20758-5)
ALBARELLI, JULIANA Q.; SANTOS, DIEGO T.; ENSINAS, V, ADRIANO; MARECHAL, FRANCOIS; COCERO, MARIA J.; MEIRELES, M. ANGELA A.. Comparison of extraction techniques for product diversification in a supercritical water gasification-based sugarcane-wet microalgae biorefinery: Thermoeconomic and environmental analysis. JOURNAL OF CLEANER PRODUCTION, v. 201, p. 697-705, . (15/13299-0, 15/06954-1, 13/18114-2, 12/10685-8)
ALBARELLI, JULIANA Q.; SANTOS, DIEGO T.; MEIRELES, M. ANGELA A.. Thermo-economic evaluation of a new approach to extract sugarcane wax integrated to a first and second generation biorefinery. BIOMASS & BIOENERGY, v. 119, p. 69-74, . (15/13299-0, 15/06954-1, 13/18114-2, 12/10685-8)
VARDANEGA, RENATA; SANTOS, DIEGO T.; MEIRELES, M. ANGELA A.. Proposal for fractionating Brazilian ginseng extracts: Process intensification approach. Journal of Food Engineering, v. 196, p. 73-80, . (13/04304-4, 10/16485-5, 12/19304-7, 12/10685-8, 13/17260-5)
ZABOT, GIOVANI L.; BITENCOURTE, IURI P.; TRES, MARCUS V.; MEIRELES, M. A. A.. Process intensification for producing powdered extracts rich in bioactive compounds: An economic approach. JOURNAL OF SUPERCRITICAL FLUIDS, v. 119, p. 261-273, . (12/10685-8, 14/15685-1, 15/13299-0)
VARDANEGA, RENATA; CARVALHO, PEDRO I. N.; SANTOS, DIEGO T.; MEIRELES, M. ANGELA A.. Obtaining prebiotic carbohydrates and beta-ecdysone from Brazilian ginseng by subcritical water extraction. INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES, v. 42, p. 73-82, . (13/04304-4, 12/10685-8)
ALCAZAR-ALAY, SYLVIA C.; OSORIO-TOBON, J. FELIPE; FORSTER-CARNEIRO, TANIA; MEIRELES, M. ANGELA A.. Obtaining bixin from semi-defatted annatto seeds by a mechanical method and solvent extraction: Process integration and economic evaluation. Food Research International, v. 99, n. 1, p. 393-402, . (12/10685-8)
SILVA, ERIC KEVEN; MEIRELES, M. ANGELA A.. Influence of the degree of inulin polymerization on the ultrasound-assisted encapsulation of annatto seed oil. Carbohydrate Polymers, v. 133, p. 578-586, . (12/10685-8)
ALBARELLI, JULIANA Q.; SANTOS, DIEGO T.; ENSINAS, ADRIANO V.; MARECHAL, FRANCOIS; COCERO, MARIA J.; MEIRELES, M. ANGELA A.. Product diversification in the sugarcane biorefinery through algae growth and supercritical CO2 extraction: Thermal and economic analysis. RENEWABLE ENERGY, v. 129, n. B, SI, p. 776-785, . (15/06954-1, 13/18114-2, 12/10685-8, 15/13299-0)
SILVA, ERIC KEVEN; ZABOT, GIOVANI L.; CAZARIN, CINTHIA B. B.; MAROSTICA, JR., MARIO R.; MEIRELES, M. ANGELA A.. Biopolymer-prebiotic carbohydrate blends and their effects on the retention of bioactive compounds and maintenance of antioxidant activity. Carbohydrate Polymers, v. 144, p. 149-158, . (12/10685-8, 14/15685-1, 15/13299-0)
ALBARELLI, JULIANA Q.; SANTOS, DIEGO T.; COCERO, MARIA JOSE; MEIRELES, MARIA ANGELA A.. Perspectives on the integration of a supercritical fluid extraction plant to a sugarcane biorefinery: thermo-economical evaluation of CO2 recycle systems. FOOD SCIENCE AND TECHNOLOGY, v. 38, n. 1, p. 13-18, . (15/06954-1, 13/18114-2, 12/10685-8, 12/19304-7, 15/13299-0, 10/16485-5)
VARDANEGA, RENATA; CARVALHO, PEDRO I. N.; ALBARELLI, JULIANA Q.; SANTOS, DIEGO T.; MEIRELES, ANGELA A.. Techno-economic evaluation of obtaining Brazilian ginseng extracts in potential production scenarios. FOOD AND BIOPRODUCTS PROCESSING, v. 101, p. 45-55, . (13/18114-2, 10/16485-5, 12/19304-7, 15/06954-1, 12/10685-8, 09/17234-9)
J. Q. ALBARELLI; A. MIAN; D. T. SANTOS; A. V. ENSINAS; F. MARÉCHAL; M. A. A. MEIRELES. Multi-objective Optimization of Supercritical Water Gasification of Leftover Brazilian Ginseng Roots After Phytochemical Recovery Steps. Brazilian Journal of Chemical Engineering, v. 34, n. 3, p. 841-850, . (12/10685-8, 12/19304-7, 09/17234-9, 10/16485-5, 13/18114-2, 15/06954-1)
SANTANA, ADINA L.; SANTOS, DIEGO T.; MEIRELES, M. ANGELA A.. Perspectives on small-scale integrated biorefineries using supercritical CO2 as a green solvent. CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, v. 18, p. 1-12, . (12/10685-8, 15/13299-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
Filed patent(s) as a result of this research project

PROCESSO DE OBTENÇÃO DE UMA COMPOSIÇÃO ANTIOXIDANTE A PARTIR DE JABUTICABA, USO DE UMA COMPOSIÇÃO ANTIOXIDANTE COMPREENDENDO EXTRATO SUPERCRÍTICO NA PREPARAÇÃO DE PRODUTOS PROBIÓTICOS E DITOS PRODUTOS PROBIÓTICOS BR1020130334162 - Universidade Estadual de Campinas (UNICAMP) . Maria Angela De Almeida Meireles; José De Assis Fonseca Faria; Rodrigo Nunes Cavalcanti; Adriano Gomes da Cruz - December 2013, 19