REM sleep deprivation impairs muscle regeneration in rats

Autor(es)

Monico-Neto, Marcos ; Dattilo, Murilo ; Ribeiro, Daniel Araki ; Lee, Kil Sun ; de Mello, Marco Tulio ; Tufik, Sergio ; Moreira Antunes, Hanna Karen

• Tipo de documento: Artigo Científico
• Fonte: GROWTH FACTORS; v. 35, n. 1, p. 12-18, 2017.
• Citações Web of Science: 3

Resumo

Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers. Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration. (AU)

• Processo FAPESP: 13/00152-5 - Efeito do exercício físico resistido no músculo esquelético e cardíaco de ratos Wistar submetidos a privação de sono paradoxal
• Beneficiário: Hanna Karen Moreira Antunes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/11056-1 - Efeitos da privação de sono no processo de recuperação muscular
• Beneficiário: Murilo Dattilo
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 11/15962-7 - Efeitos do exercício físico resistido nas vias tróficas e atróficas da musculatura esquelética de ratos submetidos à privação de sono paradoxal
• Beneficiário: Marcos Mônico Neto
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs