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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Magnetic, but not non-magnetic, reduced graphene oxide in spinal cord increases nociceptive neuronal responsiveness

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Autor(es):
Manzo, Luis Paulo ; Ceragioli, Helder ; Bonet, Ivan Jose ; Nishijima, Catarine Massucato ; Vieira, Willians Fernando ; Oliveira, Elaine Conceicao ; Destro-Filho, Joao-Batista ; Sartori, Cesar Renato ; Tambeli, Claudia Herrera ; Parada, Carlos Amilcar
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: Nanomedicine-Nanotechnology Biology and Medicine; v. 13, n. 5, p. 1841-1851, JUL 2017.
Citações Web of Science: 1
Resumo

The interference between external magnetic fields and neurophysiology is not new, however, the role of the neuronal magnetic field remains unclear. This study aimed at investigating a possible role of the neuronal magnetic field in nociception. Highly and poorly magnetic reduced graphene oxide (rGO) was injected intrathecally in rats. Nociceptive responsiveness was greater in rats that received highly magnetic-rGO in von Frey electronic or intraplantar capsaicin tests. Furthermore, in vitro experiments demonstrated that the number of KCl-responsive DRG-neurons was greater when treated with highly magnetic-rGO when compared with non-magnetic-rGO. Our data also suggested that the mechanism underlying the increased nociceptive responsiveness involves increased Ca-v(2+) activity. Complementary experiments excluded the cytotoxic and inflammatory effects of the magnetic-rGO in neuronal responsiveness. These data suggest that the disturbance of the neuronal magnetic field in spinal cord increases nociceptive responsiveness, suggesting an importance of the magnetic component of the electromagnetic field in neuronal transmission. (C) 2017 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 13/08211-0 - Influência de nanopartículas magnetizadas na sensibilização de neurônios nociceptivos
Beneficiário:Luis Paulo Manzo
Linha de fomento: Bolsas no Brasil - Doutorado