| Texto completo | |
| Autor(es): |
Cerni, Felipe Augusto
;
Pucca, Manuela Berto
;
Zoccal, Karina Furlani
;
Frantz, Fabiani Gai
;
Faccioli, Lucia Helena
;
Arantes, Eliane Candiani
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Toxicon; v. 134, p. 18-25, AUG 2017. |
| Citações Web of Science: | 2 |
| Resumo | |
Tityus serrulatus (Ts) venom is composed of a mixture of toxins presenting diverse biological functions. However, although this venom has been studied over the past three decades, omits analysis revealed that most of its toxins are not identified or their biological activities are unknown. Ts19 Frag-II is included in this group, which function is still uncertain. This study aimed to expand the biological activities of Ts19 Frag-II through in vivo investigation. Our results demonstrates that mice challenged with Ts19 Frag-II presented biochemical alterations, increasing serum levels of urea, ALT and beta-globulin, besides decreasing gamma-globulins. Moreover, this toxin was also able to induce immunological alterations, increasing NO, IL-6, TNF-alpha and IL-17, being considered a proinflammatory toxin. The increase of IL-17 was unprecedented regarding Ts toxins and could be a result of the overall produced-effect of cells of innate immunity cells (neutrophils, monocytes, natural killers and lymphoid tissue inducers - LTis) as well as of adaptive immunity (Th17 cells). This study expanded the biological activities of Ts19 Frag-II, suggesting that this toxin could be contributing to the Ts envenoming through alterations of biochemical parameters as well as triggering the inflammatory response. (C) 2017 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 14/07125-6 - Novos aspectos funcionais dos eicosanóides |
| Beneficiário: | Lúcia Helena Faccioli |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 13/21329-0 - Caracterização eletrofisiológica das toxinas provenientes da peçonha de Tityus serrulatus Ts3, Ts4, Ts6, Ts8, Ts15 e TS venom peptide 7: busca de novas drogas terapêuticas |
| Beneficiário: | Manuela Berto Pucca |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |
| Processo FAPESP: | 14/03332-7 - Estudo da relação entre ativação do inflamassoma e produção de mediadores lipídicos com a inflamação pulmonar induzida por veneno de escorpião com e sem hialuronidase |
| Beneficiário: | Karina Furlani Zoccal |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/21342-7 - Caracterização eletrofisiológica da Ts19 fragmento II, uma nova toxina purificada da peçonha de Tityus serrulatus |
| Beneficiário: | Felipe Augusto Cerni |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |