| Texto completo | |
| Autor(es): |
Zumoffen, Carlos
;
Gomez-Elias, Matias D.
;
Caille, Adriana M.
;
Bahamondes, Luis
;
Cuasnicu, Patricia S.
;
Cohen, Debora J.
;
Jose Munuce, Maria
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Contraception; v. 95, n. 6, p. 586-591, JUN 2017. |
| Citações Web of Science: | 2 |
| Resumo | |
Objective: Ulispristal acetate (UPA) is a selective progesterone receptor modulator widely used for emergency contraception (EC). The described main mechanism of action is by inhibiting or delaying ovulation; however, the postovulatory effects of the drug are still on debate. Therefore, the aim of this study was to determine whether UPA could interfere with human sperm fertilizing ability. Study design: Human motile spermatozoa were incubated under capacitating conditions with or without UPA, and then used to inseminate human tubal explants, mouse cumulus-oocyte complexes and zona-free hamster eggs. The ability of UPA to interact with human sperm progesterone (P)-binding sites was investigated by incubating the cells with fluorescent-labeled P and analyzing them by fluorescence microscopy. Results: UPA did not affect the ability of human sperm to bind to human tubal tissue explants surface or to penetrate the mouse cumulus mass and the zona-free hamster eggs. In addition, concentrations of UPA much higher than those present in the plasma of EC pill users were required to bind to human sperm P-binding sites. Conclusions: Our study supports a lack of an agonist or antagonist action of UPA on different functional parameters associated with the fertilizing ability of human sperm. (C) 2017 Elsevier Inc. All rights reserved. (AU) | |
| Processo FAPESP: | 15/20504-9 - Manifestações clínicas de usuárias de contraceptivos de somente progestogênios |
| Beneficiário: | Luis Guillermo Bahamondes |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |