Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Autor(es)

Edivaldo Massazo Utiyama ^[1] ; Maria Beatriz Sartor de Faria Rosa ^[2] ; Marina de Paula Andres ^[3] ; Jocielle Santos de Miranda ^[4] ; Sérgio Henrique Bastos Damous ^[5] ; Cláudio Augusto Vianna Birolini ^[6] ; Luciana Lamarão Damous ^[7] ; Edna Frasson de Souza Montero ^[8]

Afiliação do(s) autor(es)

^[1] Sao Paulo University. Medical School. Department of Surgery - Brasil

^[2] USP. Medical School - Brasil

^[3] USP. Medical School - Brasil

^[4] USP. Medical School. Department of Surgery - Brasil

^[5] USP. Medical School. Department of Surgery - Brasil

^[6] USP. Medical School. Department of Surgery - Brasil

^[7] USP. Medical School. Department of Obstetrics and Gynecology - Brasil

^[8] USP. Medical School. Department of Surgery - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 30, n. 6, p. 376-381, 2015-06-00.

Resumo

PURPOSE: To compare the inflammatory response of three different meshes on abdominal hernia repair in an experimental model of incisional hernia.METHODS: Median fascial incision and skin synthesis was performed on 30 Wistar rats. After 21 days, abdominal hernia developed was corrected as follows: 1) No mesh; 2) Polypropylene mesh; and, 3) Ultrapro(r) mesh. After 21 days, the mesh and surrounding tissue were submitted to macroscopic (presence of adhesions, mesh retraction), microscopic analysis to identify and quantify the inflammatory and fibrotic response using a score based on a predefined scale of 0-3 degrees, evaluating infiltration of macrophages, giant cells, neutrophils and lymphocytes.RESULTS: No significant difference was seen among groups in adherences, fibrosis, giant cells, macrophages, neutrophils or lymphocytes (p>0.05). Mesh shrinkage was observed in all groups, but also no difference was observed between polypropylene and Ultrapro mesh (7.0±9.9 vs. 7.4±10.1, respectively, p=0.967). Post-operatory complications included fistula, abscess, dehiscence, serohematic collection and reherniation, but with no difference among groups (p=0.363).CONCLUSION:There is no difference between polypropylene (high-density) and Ultrapro(r) (low-density) meshes at 21 days after surgery in extraperitoneal use in rats, comparing inflammatory response, mesh shortening, adhesions or complications. (AU)

• Processo FAPESP: 11/06111-3 - Estudo comparativo de três diferentes telas (polipropileno, poliglecaprone e poliglecaprone com filme) na reparação de hérnia incisional em ratos
• Beneficiário: Maria Beatriz Sartor de Faria
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica