Concordance of Beta-papillomavirus across anogenital and oral anatomic sites of men: The HIM Study

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Nunes, Emily M. ; Lopez, Rossana V. M. ; Sudenga, Staci L. ; Gheit, Tarik ; Tommasino, Massimo ; Baggio, Maria L. ; Ferreira, Silvaneide ; Galan, Lenice ; Silva, Roberto C. ; Lazcano-Ponce, Eduardo ; Giuliano, Anna R. ; Villa, Luisa L. ; Sichero, Laura ; Grp, HIM Study

• Tipo de documento: Artigo Científico
• Fonte: VIROLOGY; v. 510, p. 55-59, OCT 2017.
• Citações Web of Science: 7

Resumo

We evaluated the concordance between beta-HPVs detected in external genital skin, anal canal, and oral cavity specimens collected simultaneously from 717 men that were participating in the multinational HIM Study. Viral genotyping was performed using the Luminex technology. Species- and type-specific concordance was measured using kappa statistics for agreement. Overall, concordance of P-HPVs across sites was low and mainly observed among paired genital/anal canal samples. When grouped by species, solely beta-4 HPVs showed moderate concordance in genital/anal pairs (k = 0.457), which could be attributed to the substantial concordance of HPV-92 in men from Brazil and Mexico (k > 0.610). beta-HPV type concordance was higher in Mexico, where HPV-19 was consistently concordant in all anatomic site combinations. Our analysis indicates that type-specific concordance across sites is limited to few viral types; however, these infections seem to occur more often than would be expected by chance, suggesting that although rare, there is agreement among sites. (AU)

• Processo FAPESP: 13/01440-4 - Prevalência e diversidade de Beta-papillomavirus em amostras anogenitais e orais de homens do estudo HIM
• Beneficiário: Laura Cristina Sichero Vettorazzo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/20470-1 - Prevalência e diversidade de Beta-papilomavírus em amostras anogenitais e orais de homens do estudo HIM
• Beneficiário: Emily Montosa Nunes
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/12557-5 - Prevalência e fatores de risco associados à detecção de Beta-papilomavirus em amostras anogenitais e orais de homens participantes do Estudo HIM
• Beneficiário: Emily Montosa Nunes
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado
• Processo FAPESP: 08/57889-1 - Instituto de Ciência e Tecnologia para o Estudo das Doenças Associadas ao Papilomavírus
• Beneficiário: Luisa Lina Villa
• Modalidade de apoio: Auxílio à Pesquisa - Temático