Peptide dendrimers: drug/gene delivery and other approaches

Autor(es)

Santos, S. S. ; Gonzaga, R. V. ; Silva, J. V. ; Savino, D. F. ; Prieto, D. ; Shikay, J. M. ; Silva, R. S. ; Paulo, L. H. A. ; Ferreira, E. I. ; Giarolla, J.

• Tipo de documento: Artigo de Revisão
• Fonte: Canadian Journal of Chemistry; v. 95, n. 9, p. 907-916, SEP 2017.
• Citações Web of Science: 12

Resumo

Dendrimers are versatile hyperbranched molecules, which have deserved attention especially for their potential in many applications, including biological. Peptide dendrimers comprise interesting classes of dendrimers, and their use has been emphasized as a drug/bioactive compound delivery system, mostly in the antineoplastic area. The bioactive molecules can be covalently linked or entrapped inside the peptide derivative. Self-assembled nanocarriers are a recent trend in the design of potential delivery systems, and pH-sensitive carriers, one of their methods, have been designed to control their systems. In addition, the use of targeting peptides or other specific groups that direct the drug/bioactive compounds to specific organs is an important trend in the search for better drug delivery systems. Recent examples have been given in the literature, showing that gene delivery as another important peptide dendrimer application. It is worth emphasizing that some peptide dendrimers show activity per se, without bioactive compounds. Immune compounds and vaccines are presented herein, as well as uses of other peptide dendrimers are briefly discussed in this review, which encompasses around 10 years of work. (AU)

• Processo FAPESP: 16/11555-1 - Caracterização, purificação e estudos de estabilidade química e enzimática de intermediários de síntese e de fármaco dirigido dendrimérico potencialmente ativo em Doença de Chagas
• Beneficiário: Jennifer Midori Shikay
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 15/19438-1 - Síntese e estudos de liberação de compostos bioativos a partir de pró-fármacos e fármacos dirigidos dendriméricos potencialmente ativos em doenças negligenciadas
• Beneficiário: Jeanine Giarolla Vargas
• Modalidade de apoio: Auxílio à Pesquisa - Regular