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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Soft nanocomposites of gelatin and poly(3-hydroxybutyrate) nanoparticles for dual drug release

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Autor(es):
Bini, Rafael A. ; Silva, Monica F. ; Varanda, Laudemir C. ; da Silva, Marcelo A. ; Dreiss, Cecile A.
Número total de Autores: 5
Tipo de documento: Artigo Científico
Fonte: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 157, p. 191-198, SEP 1 2017.
Citações Web of Science: 8
Resumo

We developed a nanocomposite gel composed of gelatin and poly(3-hydroxybutyrate) polyineric nanoparticles (PNP) to be used as an injectable gel for the contemporaneous, dual sustained release of bioactive molecules. The hydrogel matrix was formed by a very simple process, using either the physical gelation of gelatin or the natural enzyme transglutaminase to covalently cross-link the gelatin chains in the presence of embedded PNP. Oscillatory rheological measurements showed that the addition of the PNP induced an increase in the storage modulus compared to pure gelatin gels, for both physical and chemical gels. Micrographs from scanning electron microscopy revealed that the presence of PNP disrupted the native structure of the gelatin chains in the hydrogel matrix. Dual drug encapsulation was achieved with curcumin (CM) in the PNP and naproxen sodium(NS) in the gelatin matrix. In vitro release studies showed that the hydrogel matrix acts both as a physical and chemical barrier, delaying the diffusion of the drugs. An initial burst release was observed in the first hours of the measurement, and around 90% was released on the third day for naproxen sodium. In free PNP, 82% of curcumin was relased after four days, while when PNP were embedded in the gelatin matrix only 40% was released over the same time period. Overall, these simple, sustainable soft nanocomposites show potential as an injectable co-sustained drug release system. (C) 2017 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 13/01284-2 - Nanopartículas teranósticas a base de óxido de ferro superparamagnético para terapia de câncer da pele via hipertermia magnética
Beneficiário:Laudemir Carlos Varanda
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 07/07919-9 - Nanocristais magnéticos coloidais: obtenção de nanoesferas, nanofios e nanobastões auto-organizados e funcionalizados com macromoléculas para aplicação em gravação magnética avançada, biotecnologia e biomedicina
Beneficiário:Laudemir Carlos Varanda
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores