| Texto completo | |
| Autor(es): |
da Silva Santos, Ana Carolina
;
Jensen, Jose Ricardo
;
de Oliveira, Silvio Luis
;
Rodrigues, Josias
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | GUT PATHOGENS; v. 9, AUG 7 2017. |
| Citações Web of Science: | 0 |
| Resumo | |
Background: Dysbiosis is linked to the cause of several human diseases, many of which having an immunity related component. This work investigated whether mice genetically selected for low or high antibody production display differences in intestinal bacterial communities, and consisted in the comparison of fecal 16SV6-V8 rDNA PCR amplicons resolved by temperature gradient gel electrophoresis (TGGE) of five each of low (LIII) and high (HIII) antibody producing mice. 16SV6 rDNA amplicons of 2 mice from each line were sequenced. Results: LIII mice were grouped in a single TGGE cluster, displayed a low a-diversity, and were distinguished by low Firmicutes/Bacteroidetes ratio. Conclusion: The results suggest that genetically driven low antibody production in mice is associated with gut dysbiosis. (AU) | |
| Processo FAPESP: | 12/18469-2 - Determinação da biodiversidade e atividade de bactérias da mucosa intestinal de portadores de retocolite ulcerativa e Doença de Crohn através da análise da região V6 do 16SrDNA |
| Beneficiário: | Josias Rodrigues |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |