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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Functionalized Multiwalled Carbon Nanotube Electrochemical Sensor for Determination of Anticancer Drug Flutamide

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Autor(es):
Farias, Julianna Santos ; Zanin, Hudson ; Caldas, Adriana Silva ; Dos Santos, Clenilton Costa ; Damos, Flavio Santos ; Silva Luz, Rita de Cassia
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ELECTRONIC MATERIALS; v. 46, n. 10, p. 5619-5628, OCT 2017.
Citações Web of Science: 9
Resumo

An electrochemical sensor based on functionalized multiwalled carbon nanotubes (MWCNTf) has been developed and applied for determination of anticancer drug flutamide in pharmaceutical and artificial urine samples. The electrode was prepared by modifying a glassy carbon electrode with MWCNTf, denoted herein as MWCNTf/GCE. The MWCNTf/GCE electrode exhibited high catalytic activity, high sensitivity, and high stability and was applicable over a wide concentration range for flutamide. The effects of the scan rate, pH, and nature of the electrolyte on the electrochemical behavior of flutamide on the MWCNTf/GCE were investigated. The results showed that this electrode presented the best square-wave voltammetric response to flutamide in Britton-Robinson buffer solution at pH 5.0 at frequency of 50 Hz and amplitude of 0.06 V. The proposed sensor presents a wide linear response range from concentration of 0.1 mu mol L-1 up to 1000 mu mol L-1 (or 27.6 mu g L-1 up to 0.27 g L-1), with limit of detection, limit of quantification, and sensitivity of 0.03 mu mol L-1, 0.1 mu mol L-1, and 0.30 mu A mu mol(-1) L, respectively. The MWCNTf/GCE electrode was successfully applied for determination of flutamide in pharmaceutical formulations and artificial urine samples, giving results in agreement with those obtained by a comparative method described in literature. A paired Student's t-test revealed no statistical difference between the reference and proposed method at 95% confidence level. The average recovery for fortified samples was 101 +/- 1%. (AU)

Processo FAPESP: 14/02163-7 - Desenvolvimento de dispositivos supercapacitores a partir de grafenos, nanotubos de carbono e diamantes
Beneficiário:Hudson Giovani Zanin
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores