Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Functionalized Multiwalled Carbon Nanotube Electrochemical Sensor for Determination of Anticancer Drug Flutamide

Full text
Author(s):
Farias, Julianna Santos ; Zanin, Hudson ; Caldas, Adriana Silva ; Dos Santos, Clenilton Costa ; Damos, Flavio Santos ; Silva Luz, Rita de Cassia
Total Authors: 6
Document type: Journal article
Source: JOURNAL OF ELECTRONIC MATERIALS; v. 46, n. 10, p. 5619-5628, OCT 2017.
Web of Science Citations: 9
Abstract

An electrochemical sensor based on functionalized multiwalled carbon nanotubes (MWCNTf) has been developed and applied for determination of anticancer drug flutamide in pharmaceutical and artificial urine samples. The electrode was prepared by modifying a glassy carbon electrode with MWCNTf, denoted herein as MWCNTf/GCE. The MWCNTf/GCE electrode exhibited high catalytic activity, high sensitivity, and high stability and was applicable over a wide concentration range for flutamide. The effects of the scan rate, pH, and nature of the electrolyte on the electrochemical behavior of flutamide on the MWCNTf/GCE were investigated. The results showed that this electrode presented the best square-wave voltammetric response to flutamide in Britton-Robinson buffer solution at pH 5.0 at frequency of 50 Hz and amplitude of 0.06 V. The proposed sensor presents a wide linear response range from concentration of 0.1 mu mol L-1 up to 1000 mu mol L-1 (or 27.6 mu g L-1 up to 0.27 g L-1), with limit of detection, limit of quantification, and sensitivity of 0.03 mu mol L-1, 0.1 mu mol L-1, and 0.30 mu A mu mol(-1) L, respectively. The MWCNTf/GCE electrode was successfully applied for determination of flutamide in pharmaceutical formulations and artificial urine samples, giving results in agreement with those obtained by a comparative method described in literature. A paired Student's t-test revealed no statistical difference between the reference and proposed method at 95% confidence level. The average recovery for fortified samples was 101 +/- 1%. (AU)

FAPESP's process: 14/02163-7 - Development of supercapacitors devices from graphene, carbon nanotubes and diamonds
Grantee:Hudson Giovani Zanin
Support type: Research Grants - Young Investigators Grants