Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Nanostructured Alpha-NiCe Mixed Hydroxide for Highly Sensitive Amperometric Prednisone Sensors

Texto completo
Autor(es):
Goncalves, Josue M. ; Guimaraes, Robson R. ; Brandao, Bruno B. N. S. ; Saravia, Lucas P. H. ; Rossini, Pamela O. ; Nunes, Jr., Cicero V. ; Bernardes, Juliana S. ; Berttoti, Mauro ; Angnes, Lucio ; Araki, Koiti
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: Electrochimica Acta; v. 247, p. 30-40, SEP 1 2017.
Citações Web of Science: 7
Resumo

Nickel hydroxide nanoparticles with enhanced electrocatalytic activity and stability in the alpha phase were prepared by incorporation of 20 atom% of Ce(III) ions, that were shown to be oxidized to the catalytic active Ce(IV) species in the mixed hydroxide/oxide nanomaterial. Alpha-NiCe is constituted by smaller nanoparticles as compared with pure nickel hydroxide and can interact with prednisone, a widely prescribed medicine that is controlled by the International Anti-Doping Agency because of its use as anabolic agent. This compound is more or less easily hydroxilated by oxygen and then oxidized to the respective keto species, that was shown to be oxidized further by the modified electrodes upon loss of the alkyl side chain. Thus, a sensitive prednisone sensor was demonstrated exploring the electrocatalytic oxidation reaction instead of the reduction of prednisone to prednisolone, as previously reported in the literature. Sensitivity as high as 3.9 x 10(-2) A mol(-1) L/cm(2) and limit of detection as low as 8.4 x 10(-9) mol L-1 were achieved using flow injection analyses. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 13/24725-4 - Química supramolecular e nanotecnologia
Beneficiário:Henrique Eisi Toma
Linha de fomento: Auxílio à Pesquisa - Temático