Stability Study of Hypervalent Tellurium Compounds in Aqueous Solutions

Autor(es)

Princival, Cleverson R. ; Archilha, Marcos V. L. R. ; Dos Santos, Alcindo A. ; Franco, Mauricio P. ; Braga, Ataualpa A. C. ; Rodrigues-Oliveira, Andre F. ; Correra, Thiago C. ; Cunha, Rodrigo L. O. R. ; Comasseto, Joao V.

• Tipo de documento: Artigo Científico
• Fonte: ACS OMEGA; v. 2, n. 8, p. 4431-4439, AUG 2017.
• Citações Web of Science: 3

Resumo

Hypervalent tellurium compounds (telluranes) are promising therapeutical agents with negligible toxicities for some diseases in animal models. The C-Te bond of organotellurium compounds is commonly considered unstable, disfavoring their applicability in biological studies. In this study, the stability of a set of telluranes composed of an inorganic derivative and noncharged and charged organic derivatives was monitored in aqueous media with H-1, C-13, and Te-125 NMR spectroscopy and high-resolution mass spectrometry. Organic telluranes were found to be remarkably resistant and stable to hydrolysis, whereas the inorganic tellurane AS101 is totally converted to the hydrolysis product, trichlorooxytellurate, {[}TeOCl3](-), which was also observed in the hydrolysis of TeCl4. The noteworthy stability of organotelluranes in aqueous media makes them prone to further structure-activity relationship studies and to be considered for broad biological investigations. (AU)

• Processo FAPESP: 14/15962-5 - Mecanismos de reação de sistemas catalíticos assimétricos por espectrometria de massas e espectroscopia vibracional de íons na fase gasosa
• Beneficiário: Thiago Carita Correra
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
• Processo FAPESP: 15/08539-1 - EMU concedido no processo 2014/15962-5: espectrômetro de massas tipo íon TRAP modificado para realização de espectroscopia vibracional no infravermelho (IRMPD)
• Beneficiário: Thiago Carita Correra
• Linha de fomento: Auxílio à Pesquisa - Programa Equipamentos Multiusuários