| Full text | |
| Author(s): |
Princival, Cleverson R.
;
Archilha, Marcos V. L. R.
;
Dos Santos, Alcindo A.
;
Franco, Mauricio P.
;
Braga, Ataualpa A. C.
;
Rodrigues-Oliveira, Andre F.
;
Correra, Thiago C.
;
Cunha, Rodrigo L. O. R.
;
Comasseto, Joao V.
Total Authors: 9
|
| Document type: | Journal article |
| Source: | ACS OMEGA; v. 2, n. 8, p. 4431-4439, AUG 2017. |
| Web of Science Citations: | 3 |
| Abstract | |
Hypervalent tellurium compounds (telluranes) are promising therapeutical agents with negligible toxicities for some diseases in animal models. The C-Te bond of organotellurium compounds is commonly considered unstable, disfavoring their applicability in biological studies. In this study, the stability of a set of telluranes composed of an inorganic derivative and noncharged and charged organic derivatives was monitored in aqueous media with H-1, C-13, and Te-125 NMR spectroscopy and high-resolution mass spectrometry. Organic telluranes were found to be remarkably resistant and stable to hydrolysis, whereas the inorganic tellurane AS101 is totally converted to the hydrolysis product, trichlorooxytellurate, {[}TeOCl3](-), which was also observed in the hydrolysis of TeCl4. The noteworthy stability of organotelluranes in aqueous media makes them prone to further structure-activity relationship studies and to be considered for broad biological investigations. (AU) | |
| FAPESP's process: | 14/15962-5 - Reaction mechanism of asymmetric catalysts by mass spectrometry and gas-phase vibrational ion spectroscopy |
| Grantee: | Thiago Carita Correra |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 15/08539-1 - Multi-User Equipment approved in grant 2014/15962-5: ion trap mass spectrometer modified to perform infrared vibrational spectroscopy (IRMPD) |
| Grantee: | Thiago Carita Correra |
| Support Opportunities: | Multi-user Equipment Program |