Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

Autor(es)

Siqueira, Lilian ; de Paula, Cynthia Guimaraes ; Motisuke, Mariana ; Gouveia, Rubia Figueredo ; Afonso Camargo, Samira Esteves ; Moreira Milhan, Noala Vicensoto ; Triches, Eliandra de Sousa

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 20, n. 4, p. 973-983, JUL-AUG 2017.
• Citações Web of Science: 1

Resumo

Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. beta-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, beta-TCP and beta-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (8688%) and pore sizes ranging from 200 to 500 mu m. Even though alumina did not promote improvement in beta-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, beta-TCP and beta-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. (AU)

• Processo FAPESP: 10/00863-0 - Processamento e caracterização de suportes porosos nanoestruturados do tipo B-TCP/Al2O3 para aplicações biomédicas
• Beneficiário: Eliandra de Sousa Trichês
• Modalidade de apoio: Auxílio à Pesquisa - Regular