Cytological and cytomorphometric evaluation of the oral mucosa in HIV-infected patients undergoing antiretroviral therapy

Autor(es)

Oliveira Alves, Monica Ghislaine ^{[1, 2]} ; Lima Carta, Celina Faig ^{[1, 2]} ; Haberbeck Brandao, Adriana Aigotti ^[1] ; Duailibe Furtado, Juvencio Jose ^[3] ; Marcucci, Marcelo ^[4] ; Almeida, Janete Dias ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, UNESP, Sao Jose Dos Campos, SP - Brazil

^[2] Univ Braz Cubas, Sch Dent, Mogi Das Cruzes - Brazil

^[3] Heliopolis Hosp, Dept Infect Dis, Sao Paulo - Brazil

^[4] Heliopolis Hosp, Dept Stomatol & Maxillofacial Surg, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 46, n. 9, p. 840-845, OCT 2017.
• Citações Web of Science: 0

Resumo

Background: To evaluate HIV infection-induced alterations in the oral mucosa by comparing inflammation, cell maturation, and cytomorphometric changes in oral mucosal cells between HIV-infected patients undergoing highly active antiretroviral therapy (HAART) and non-HIV-infected patients. Methods: Thirty HIV-infected patients undergoing HAART and 30 non-HIV-infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush. One sample was stained by the Papanicolaou technique, and three samples were processed for Feulgen staining. Papanicolaou-stained smears were analyzed by light microscopy, and the cytoplasmic (CA) and nuclear (NA) area were measured with the Software AxioVision 4.7. Results: The Wilcoxon signed-rank test showed a significant difference in intermediate epithelial cell types between the HIV-infected and non-HIV-infected groups (P=.005). However, this difference was not observed for superficial epithelial cell types with (P=.672) and without a nucleus (P=.069). Comparative analysis revealed no significant difference in CA (P=.604), NA (P=.298) or NA/CA (P=.456) between the HIV-infected and non-HIV-infected groups. Keratohyalin granules were more frequent in the non-HIV-infected group (P=.0001). Conclusions: The results showed alterations in cell maturation in HIV-infected patients undergoing HAART with undetectable viral load, but no morphometric changes were observed. (AU)

• Processo FAPESP: 12/05062-1 - Estudo citológico da mucosa bucal de portadores do vírus HIV
• Beneficiário: Janete Dias Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Regular