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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytological and cytomorphometric evaluation of the oral mucosa in HIV-infected patients undergoing antiretroviral therapy

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Author(s):
Oliveira Alves, Monica Ghislaine [1, 2] ; Lima Carta, Celina Faig [1, 2] ; Haberbeck Brandao, Adriana Aigotti [1] ; Duailibe Furtado, Juvencio Jose [3] ; Marcucci, Marcelo [4] ; Almeida, Janete Dias [1]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ, Inst Sci & Technol, Dept Biosci & Oral Diag, UNESP, Sao Jose Dos Campos, SP - Brazil
[2] Univ Braz Cubas, Sch Dent, Mogi Das Cruzes - Brazil
[3] Heliopolis Hosp, Dept Infect Dis, Sao Paulo - Brazil
[4] Heliopolis Hosp, Dept Stomatol & Maxillofacial Surg, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 46, n. 9, p. 840-845, OCT 2017.
Web of Science Citations: 0
Abstract

Background: To evaluate HIV infection-induced alterations in the oral mucosa by comparing inflammation, cell maturation, and cytomorphometric changes in oral mucosal cells between HIV-infected patients undergoing highly active antiretroviral therapy (HAART) and non-HIV-infected patients. Methods: Thirty HIV-infected patients undergoing HAART and 30 non-HIV-infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush. One sample was stained by the Papanicolaou technique, and three samples were processed for Feulgen staining. Papanicolaou-stained smears were analyzed by light microscopy, and the cytoplasmic (CA) and nuclear (NA) area were measured with the Software AxioVision 4.7. Results: The Wilcoxon signed-rank test showed a significant difference in intermediate epithelial cell types between the HIV-infected and non-HIV-infected groups (P=.005). However, this difference was not observed for superficial epithelial cell types with (P=.672) and without a nucleus (P=.069). Comparative analysis revealed no significant difference in CA (P=.604), NA (P=.298) or NA/CA (P=.456) between the HIV-infected and non-HIV-infected groups. Keratohyalin granules were more frequent in the non-HIV-infected group (P=.0001). Conclusions: The results showed alterations in cell maturation in HIV-infected patients undergoing HAART with undetectable viral load, but no morphometric changes were observed. (AU)

FAPESP's process: 12/05062-1 - Oral mucosa cytological study of HIV-positive patients
Grantee:Janete Dias Almeida
Support Opportunities: Regular Research Grants