Synthesis and characterization of Mn(I) complexes and their larvicidal activity against Aedes aegypti, vector of dengue fever

Autor(es)

de Aguiar, Inara ^[1] ; dos Santos, Edjane Rocha ^[1] ; Mafud, Ana Carolina ^[2] ; Annies, Vinicius ^[3] ; Navarro-Silva, Mario Antonio ^[4] ; dos Santos Malta, Valeria Rodrigues ^[5] ; do Prado Gambardella, Maria Teresa ^[6] ; Marques, Francisco de Assis ^[3] ; Carlos, Rose Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560905 Sao Carlos, SP - Brazil

^[3] Univ Fed Parana, Dept Quim, BR-81531980 Curitiba, Parana - Brazil

^[4] Univ Fed Parana, Dept Zool, BR-81531980 Curitiba, Parana - Brazil

^[5] Univ Fed Alagoas, Inst Quim & Biotecnol, BR-57072900 Maceio, AL - Brazil

^[6] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inorganic Chemistry Communications; v. 84, p. 49-55, OCT 2017.
• Citações Web of Science: 3

Resumo

This article describes the structure (X-ray), spectroscopic properties (FTIR, UV vis, H-1 NMR) and larvicidal activity of Mn(I) complexes,fac-{[}Mn(CO)(3)(phen)(L)](+), where phen = 1,10'-phenanthroline and L = 2-methyl-imidazole, 4-methyl-imidazole, and 2-phenyl-imidazole. The mode of action on the cholinesterase enzyme activity and the Cytochrome-C (P450) inhibition are also reported. The complexes were highly effective againstA. aegypti larvae causing up to 90% mortality at 0.033 to 0.046 g/L concentration in 4 days, showing their great potential to control mosquito proliferation. The complexes do not interact with acetylcholinesterase enzyme from the A. aegypti mosquito, but react strongly with the P450 enzyme under light irradiation, reducing the Fe(III) to Fe(II). This is very important since P450 has implications on the insecticidal resistance of the mosquitoes. In addition, manganese is one of the most abundant metals on earth and an essential element for life; therefore, no harmful effect on humans or environment is expected with the use of these compounds. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 14/02282-6 - Estudo da relação estrutura-atividade de alcalóides derivados da Pilocarpus microphyllus (Rutaceae) com ação contra Schistosoma mansoni
• Beneficiário: Ana Carolina Mafud
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/08218-0 - Novos complexos do tipo Mn(I)-fotosensibilizador: modelos minéticos para o lado doador do PSII em fotossíntese artificial
• Beneficiário: Rose Maria Carlos
• Linha de fomento: Auxílio à Pesquisa - Regular