Potential human health risk assessment of cylindrospermopsin accumulation and depuration in lettuce and arugula

Autor(es)

Cordeiro-Araujo, Micheline Kezia ^{[1, 2]} ; Chia, Mathias Ahii ^{[1, 3]} ; Bittencourt-Oliveira, Maria do Carmo ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Biol Sci, Ave Padua Dias, 11, BR-13418900 Piracicaba, SP - Brazil

^[2] Rural & Fed Univ Pernambuco, Bot Grad Program, R Dorn Manoel de Medeiros, S-N, BR-52171030 Recife, PE - Brazil

^[3] Ahmadu Bello Univ, Dept Bot, Zaria 810001 - Nigeria

• Tipo de documento: Artigo Científico
• Fonte: HARMFUL ALGAE; v. 68, p. 217-223, SEP 2017.
• Citações Web of Science: 8

Resumo

The cyanobacterial toxin cylindrospermopsin (CYN) has become a globally important secondary metabolite due to the negative effect it has on human and animal health. As a means of evaluating the risk of human exposure to CYN, the bioaccumulation and depuration of the toxin in lettuce (Lactuca sativa L.) and arugula (Eruca sativa Mill.) were investigated, after irrigation, with contaminated water. The vegetables were irrigated for 7 days with CYN (3, 5 and 10 mu g/L) contaminated water (bioaccumulation phase), and subsequently, irrigated for 7 days with uncontaminated distilled water (depuration phase). In general, the bioaccumulation of CYN in both vegetables decreased with increasing exposure concentration. Bioconcentration factor (BCF) of CYN increased with the progression of the experiment at 3.0 mu g/L CYN, while the reverse occurred at 5 and 10 mu g/L CYN. In arugula, BCF increased at all CYN exposure concentrations throughout the study. The depuration of CYN decreased with increasing exposure concentration but was highest in the plants of both species with the highest bioaccumulation of CYN. Specifically, in plants previously irrigated with water contaminated with 3, 5 and 10 mu g/L. CYN, the depuration of the toxin was 60.68, 27.67 and 18.52% for lettuce, and 47, 46.21 and 27.67% for arugula, respectively. Human health risks assessment revealed that the consumption of approximately 10 to 40 g of vegetables per meal will expose children and adults to 1.00-6.00 ng CYN/kg body mass for lettuce and 2.22-7.70 ng CYN/kg body mass for arugula. The irrigation of lettuce and arugula with contaminated water containing low CYN concentrations constitutes a potential human exposure route. (C) 2017 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/11306-3 - Efeitos de anatoxina-a e cilindrospermopsina em diferentes concentrações de nitrogênio e irradiância na fisiologia de Microcystis aeruginosa (Cyanobacteria)e Scenedesmus acuminatus (Chlorophyta)
• Beneficiário: Mathias Ahii Chia
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/01934-0 - Investigação de bioacumulação e desintoxicação de toxinas de cianobactérias (microcistinas e cilindrospermopsina) em alface e rúcula
• Beneficiário: Maria Do Carmo Bittencourt de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/17397-6 - RITMO CIRCADIANO NA PRODUÇÃO E LIBERAÇÃO DE MICROCISTINAS, EXPRESSÃO DO GENE mcyE E ESTRESSE FISIOLÓGICO EM CIANOBACTÉRIAS: IMPLICAÇÕES DAS MUDANÇAS CLIMÁTICAS GLOBAIS
• Beneficiário: Micheline Kézia Cordeiro de Araújo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado