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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

THE MEDIAL PREOPTIC AREA MODULATES AUTONOMIC FUNCTION UNDER RESTING AND STRESS CONDITIONS

Texto completo
Autor(es):
Fassini, Aline [1] ; Scopinho, America A. [1] ; Alves, Fernando H. F. [1] ; Fortaleza, Eduardo A. T. [1] ; Correa, Fernando M. A. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Neuroscience; v. 364, p. 164-174, NOV 19 2017.
Citações Web of Science: 1
Resumo

The medial preoptic area (mPOA) participates in the temperature and cardiovascular control. The mPOA receives inputs from limbic structures and sends projections to hypothalamus and brainstem. Moreover, stress elicits pronounced neuronal activation in mPOA, suggesting its involvement in central neural pathway mediating stress responses. In the present study, we report the effect of acute mPOA neurotransmission inhibition using cobalt chloride (CoCl2-nonselective synapse blocker) on the mean arterial pressure (MAP), heart rate (HR), body and tail temperature (T-body and T-tail, respectively), as well as on the HR component of baroreflex. We also verified the participation of mPOA in the autonomic changes evoked by acute restraint stress (RS). Our results demonstrated that microinjection of CoCl2 into mPOA caused tachycardia, hyperthermia and a Ttail decrease, without altering MAP. The inhibition of mPOA with CoCl2 increased the sympathetic component of cardiac baroreflex when assessed 10 min after its administration. In addition, pretreatment of mPOA with CoCl2 increased RS-evoked tachycardic and hyperthermic responses evoked by RS when compared with aCSFtreated animals, without affecting the RS-evoked pressor response and the fall in Ttail. In summary, our results suggest that mPOA exerts a tonic inhibitory influence on the sympathetic cardiac tone under both rest and stress conditions, modulating negatively the sympathetic component of baroreflex. Results also confirm the mPOA involvement in the control of body temperature because its inhibition was followed by a sustained increase in body temperature and vasoconstriction in the tail artery territory. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 13/13721-8 - Estudo do envolvimento do sistema endocanabinóide do córtex pré-frontal medial ventral sobre a ingestão alimentar de ratos.
Beneficiário:América Scopinho Augusto
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 12/18556-2 - Envolvimento do sistema glutamatérgico dos núcleos paraventricular e supra-óptico na modulação do sistema cardiovascular e na liberação de vasopressina e ocitocina em ratos submetidos ao estímulo osmótico.
Beneficiário:Eduardo Albino Trindade Fortaleza
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/00249-9 - Envolvimento da neurotransmissão opioidérgica da amígdala medial na mediação das respostas autonômicas e hormonais causadas pelo estresse de restrição em ratos
Beneficiário:Aline Fassini
Linha de fomento: Bolsas no Brasil - Doutorado