Intrauterine exposure to 17 beta-oestradiol (E2) impairs postnatal development in both female and male prostate in gerbil

Autor(es)

Sanches, Bruno D. A. ^[1] ; Santos, Juliana M. ^[1] ; Zani, Bruno C. ^[1] ; Biancardi, Manoel F. ^[2] ; Santos, Fernanda C. A. ^[2] ; Goes, Rejane M. ^[3] ; Vilamaior, Patricia S. L. ^[3] ; Taboga, Sebastiao R. ^[3]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Dept Struct & Funct Biol, Bertrand Russel Av S-N, Campinas, SP - Brazil

^[2] Fed Univ Goias UFG, Dept Histol Embryol & Cell Biol, Samambaia 2, BR-74001970 Goiania, Go - Brazil

^[3] Univ Estadual Paulista, Dept Biol, Lab Microscopy & Microanal, UNESP, Cristovao Colombo St, Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 73, p. 30-40, OCT 2017.
• Citações Web of Science: 4

Resumo

We employed histological techniques to assess the effects of intrauterine exposure to different dosages of E2 on male and female Mongolian gerbils on the postnatal development of the prostate. E2 promotes alterations this gland branches in the female, but not in males, even at low dosage, at higher dosages, acini of altered aspect are verified in the male and female prostate, as well as a decrease in branching number, reduced cell proliferation and staining for FGF10, simultaneously to the increased labelling for TGF beta 1, which may account for alterations on branching of the prostate. The sensitivity of the female prostate to intrauterine exposure to E2, which can reflect the E2 dependence of female prostate development. This becomes alarming in view of the occurrence of prostate in female of several mammals and including women, and the possibility that low E2 dosage exposures considered safe to males provoke developmental alterations in female prostate. (c) 2017 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 13/15939-0 - Avaliação da exposição estrogênica intra-uterina sobre as principais vias de interações epitélio-mesenquimais envolvidas na morfogênese das ramificações do lobo ventral da próstata do Gerbilo da Mongólia (Meriones unguiculatus)
• Beneficiário: Bruno Domingos Azevedo Sanches
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 13/16443-9 - Estudo descritivo do processo de ramificação do lobo ventral da próstata do Gerbilo da Mongólia (Meriones unguiculatus)
• Beneficiário: Bruno Casagrande Zani
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica