Expression patterns of CD56+and CD16+cells in renal transplant biopsies with acute rejection: Associations with microcirculation injuries and graft survival

Autor(es)

Dos Santos, Daniela Cristina ^{[1, 2]} ; Saraiva Camara, Niels Olsen ^[3] ; Ribeiro David, Daisa Silva ^[1] ; Avancini Costa Malheiros, Denise Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Coll Med Univ, Sao Paulo - Brazil

^[2] Sao Paulo State Univ, Dept Pathol, Coll Med, Botucatu, SP - Brazil

^[3] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEPHROLOGY; v. 22, n. 12, p. 993-1001, DEC 2017.
• Citações Web of Science: 1

Resumo

BackgroundThe study investigated whether immunohistochemical features of interstitial and glomerular CD56 and CD16 infiltrates - NK cells markers - could be associated with microcirculation injury scores - peritubular capillaritis (ptc) and glomerulitis (g) - and graft survival. MethodsThe research analyzed the immunohistochemical pattern of CD56 and CD16 in interstitial and glomerular compartments of biopsies for-cause biopsies from 59 recipients diagnosed with acute rejection (mean=135.5days post-transplant). ResultsInterstitial CD56+ cells had an increased expression for glomerulitis (g1) (P=0.02) and peritubular capillaritis (ptc2) (P=0.003) presence. It was noted that interstitial CD56+cells with mean above 0.56cells/mm(2) had worse allograft survival. CD56+ cells in the interstitial compartment with mean less than or equal to 0.56cells/mm(2) was related with absence or mild peritubular capillaritis (P=0.012) and mean above 0.56cells/mm(2), respectively, with glomerulitis (P=0.002) presence. Interstitial CD16 cells showed greater positive results in relation to peritubular capillaritis (P=0.0001) cases. Similarly, it was observed that glomerular CD16+ cells had higher positive results in glomerulitis (P=0.009) presence. ConclusionsThe study findings showed that CD56+ cell infiltrated in the interstitial compartment was significantly associated with microcirculation injury scores, especially the glomerulitis, and graft survival. Summary at a Glance This study suggests that increased expression of interstitial natural killer cells in renal allograft biopsies of kidney transplant recipients with rejection may be associated with poorer graft outcomes. (AU)

• Processo FAPESP: 12/21604-9 - Estudo das células natural killer (células NK) nas rejeições mediadas por anticorpos: papel das células NK nas rejeições humorais C4d negativas
• Beneficiário: Denise Maria Avancini Costa Malheiros
• Modalidade de apoio: Auxílio à Pesquisa - Regular