Mice Behavioral Phenotype Changes after Administration of Anani (Symphonia globulifera, Clusiaceae), an Alternative Latin American and African Medicine

Autor(es)

Suffredini, Ivana Barbosa ^{[1, 2]} ; Barradas Paciencia, Mateus Luis ^{[1, 2]} ; Diaz, Ingrit E. C. ^[3] ; Frana, Sergio Alexandre ^{[1, 2]} ; Bernardi, Maria Martha ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Paulista, Grad Program Dent, Sao Paulo - Brazil

^[2] Univ Paulista, Ctr Res Biodivers Extract Lab & Herbarium, Grad Program Environm & Expt Pathol, Sao Paulo - Brazil

^[3] Natl Univ Engn, Chem & Text Engineer Faculdty, Lima - Peru

• Tipo de documento: Artigo Científico
• Fonte: PHARMACOGNOSY MAGAZINE; v. 13, n. 52, p. 617-626, OCT-DEC 2017.
• Citações Web of Science: 0

Resumo

Background: Anani, (Symphonia globulifera, Clusiaceae), known as chewstick, is a traditional plant occurring in Africa and in Central and South Americas that is used against parasites and microorganisms. Although its use is popular in some of these countries, there is a lack of information related to its influence over behavioral phenotype (BP). Objective: The objective of this study is to evaluate the influence of the administration of the extract obtained from the aerial organs of Anani (EB1257) to male Balb-c mice over BP. Materials and Methods: Open cage observation, open field, and elevated-plus maze apparatuses were used. Evaluations were done 15, 30, 60, 120, and 180 min after intraperitoneal administration of Anani extract. Results: Impairment of general behavior activity, response to touch, tail squeeze, defecation, locomotion and rearing frequency were observed although no signs of hemorrhage or macroscopical alterations of internal organs. Anani is harmful, but not toxic if used in the appropriate doses, yet to be determined to male mice. Impairment of locomotion and defecation was observed, indicating some degree of influence over locomotion, but no alterations in anxiety levels were assessed. Three compounds were previously found in the plant-lupeol (1), beta-amyrin (2) and 3-beta-hydroxyglutin-5-ene (3), and one is being described for the first time to occur in the species: oleanolic acid (4). Conclusions: The present work contributes in the support of the rational use of Anani, an important Latin American and African alternative medicine, presenting findings that are being reported for the first time. (AU)

• Processo FAPESP: 08/58706-8 - Avaliação da atividade antitumoral, antibacteriana e ação sobre o sistema nervoso central e hormônios de extratos obtidos de plantas amazônicas e da Mata Atlântica
• Beneficiário: Ivana Barbosa Suffredini
• Modalidade de apoio: Auxílio à Pesquisa - Regular