Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse outcome

Autor(es)

Sedassari, Bruno Tavares ^[1] ; Setubal Destro Rodrigues, Maria Fernanda ^[1] ; Conceicao, Thalita Santana ^[1] ; Mariano, Fernanda Viviane ^[2] ; Ferreira Alves, Venancio Avancini ^[3] ; Nunes, Fabio Daumas ^[1] ; Altemani, Albina ^[2] ; Orsini Machado de Sousa, Suzana Cantanhede ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent, Dept Oral & Maxillofacial Pathol, Ave Prof Lineu Prestes 2227, BR-05208000 Sao Paulo, SP - Brazil

^[2] Univ Estadual Campinas, Sch Med, Dept Anat Pathol, R Tessalia Vieira de Camargo 126, BR-13084971 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Anat Pathol, Ave Dr Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Virchows Archiv; v. 471, n. 6, p. 775-784, DEC 2017.
• Citações Web of Science: 2

Resumo

SOX2 is a regulatory factor of embryonic stem cells that has been implicated in carcinogenesis and cancer progression. We aimed to investigate the potential role of SOX2 in the stepwise progression from pleomorphic adenoma (PA) to invasive carcinoma ex pleomorphic adenoma (CXPA), evaluating its prognostic significance as well. Thirty PAs without malignant transformation and 25 CXPAs presenting both luminal or myoepithelial differentiation (7 intracapsular and 18 extracapsular) were evaluated immunohistochemically for SOX2 expression. Of these, 24 CXPAs (96%) were positive to SOX2, being 6 intracapsular carcinomas (85.7%) and all the 18 extracapsular carcinomas (100%). Residual PA areas and PAwithout malignant transformation were negative. High SOX2 expression levels (> 50% of positive cells) were correlated with high histological grade (p = 0.02), brisk mitotic activity (p = 0.01), advanced pT stage (p = 0.01), tumor recurrence (p = 0.01), and development of distant metastasis (p = 0.004). Still, overall survival rates were shorter in patients with extracapsular CXPA exhibiting diffuse SOX2 expression. These results suggest that SOX2 may play an important role in carcinogenesis and progression of CXPA and is also related with prognostic indicators in CXPAs with extracapsular invasion. Although direct therapeutic intervention in SOX2 may result in unwanted complications due to its constitutive functions, strategic approach to SOX2-related pathways may provide new therapeutic opportunities for patients with invasive CXPA. (AU)

• Processo FAPESP: 16/18661-1 - Estudo da diferenciação semelhante à lactacional no carcinoma secretório análogo ao de mama com origem em glândula salivar.
• Beneficiário: Bruno Tavares Sedassari
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado