Heteroresistance to Fluconazol in Clinical and Environmental Brazilian Strains of Cryptococcus neoformans/C. gattii Species Complex

Autor(es):Mostrar menos -

Feliciano, L. M. ^[1] ; Ramos, S. D. P. ^[2] ; Szeszs, M. W. ^[2] ; Martins, M. A. ^[2] ; Bonfietti, L. X. ^[2] ; Oliveira, R. A. ^[2] ; Santos, D. C. S. ^[2] ; Fadul, L. H. ^[2] ; Silva, D. F. ^[2] ; Paula, C. R. ^[3] ; Trilles, L. ^[4] ; Silva, L. E. A. ^[5] ; Ferreira-Paim, K. ^[5] ; Mora, D. J. ^[5] ; Andrade, A. A. ^[5] ; Silva, P. R. ^[5] ; Silva-Vergara, M. L. ^[5] ; Roberto, T. N. ^[6] ; Melhem, M. S. C. ^[2]

Afiliação do(s) autor(es)

^[1] Grad Program Dis Control Coordinat, Hlth, Sao Paulo - Brazil

^[2] Adolfo Lutz Inst, Mycol Dept, Rio Claro, SP - Brazil

^[3] Univ Sao Paulo, Sao Paulo - Brazil

^[4] Fundacao Oswaldo Cruz, Evandro Chagas Clin Res Inst, Rio De Janeiro - Brazil

^[5] Univ Fed Triangulo Mineiro, Disciplina Doencas Infecciosas Parasitarias, Uberaba, MG - Brazil

^[6] Sao Paulo Fed Univ, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CURRENT FUNGAL INFECTION REPORTS; v. 11, n. 4, p. 190-196, DEC 2017.
• Citações Web of Science: 1

Resumo

Purpose of Study To review the literature on heteroresistance to fluconazole (FLC) and investigate the level of heteroresistance to FLC (LHF), we analyzed 100 clinical and environmental Brazilian Cryptococcus strains. Recent Findings Heteroresistance is a phenomenon described as the emergence of resistant subpopulation cells within a single susceptible strain that can tolerate higher concentrations of fluconazole above the minimal inhibitory concentration (MIC) level. Summary We found lower FLC-MICs (0.12-64 mg/L) than LHF (8-128 mg/L). Highly heteroresistant adapted subpopulations (256 mg/L) was found in minority (9%) strains, but importantly, 33% showed low FLC-MIC (8 mg/L). We concluded for similar LHF in both species, but higher LHF in clinical strains in comparison to environmental ones. Our findings stressed that the LHF is not correlated to species and pretty is strain-dependent and alert about high heteroresistant subpopulations that hardly reverts to the original LHF even upon the removal of drug pressure. (AU)

• Processo FAPESP: 13/04567-5 - Heterorresistência ao fluconazol em agentes da criptococose
• Beneficiário: Leticia Marielle Feliciano
• Modalidade de apoio: Bolsas no Brasil - Mestrado