Ivermectin reduces motor coordination, serum testosterone, and central neurotransmitter levels but does not affect sexual motivation in male rats

Autor(es)

Moreira, N. ^[1] ; Sandini, T. M. ^[2] ; Reis-Silva, T. M. ^[3] ; Navas-Suaresz, P. ^[1] ; Auada, A. V. V. ^[4] ; Lebrun, I. ^[4] ; Florio, J. C. ^[5] ; Bernardi, M. M. ^{[6, 7]} ; Spinosa, H. S. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Grad Program Expt & Comparat Pathol, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci, Grad Program Toxicol & Toxicol Anal, Av Prof Dr Lineu Prestes 580, BR-05508000 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Inst Psychol, Dept Neurosci, Grad Program Neurosci & Behav, Av Prof Dr Melo de Morais 1721, BR-05508030 Sao Paulo, SP - Brazil

^[4] Butantan Inst, Lab Biochem & Biophys, Av Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil

^[6] Univ Paulista, Grad Program Environm & Expt Pathol, R Dr Bacelar 1212, BR-04026002 Sao Paulo, SP - Brazil

^[7] Univ Paulista, Grad Program Dent, R Dr Bacelar 1212, BR-04026002 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 74, p. 195-203, DEC 2017.
• Citações Web of Science: 5

Resumo

Ivermectin (IVM) is a macrocyclic lactone used for the treatment of parasitic infections and widely used in veterinary medicine as endectocide. In mammals, evidence indicates that IVM interacts with y-aminobutyric acid (GABA)-mediated chloride channels. GABAergic system is involved in the manifestation of sexual behavior. We previously found that IVM at therapeutic doses did not alter sexual behavior in male rats, but at a higher dose, the appetitive phase of sexual behavior was impaired. Thus, we investigated whether the reduction of sexual behavior that was previously observed was a consequence of motor or motivational deficits that are induced by IVM. Data showed significant decrease in striatal dopaminergic system activity and lower testosterone levels but no effects on sexual motivation or penile erection. These findings suggest IVM may activate the GABAergic system and reduce testosterone levels, resulting in a reduction of motor coordination as consequence of the inhibition of striatal dopamine release. (C) 2017 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 15/03131-4 - Efeitos da exposição à ivermectina em ratos: aspectos reprodutivos em machos e fêmeas
• Beneficiário: Natalia Moreira
• Linha de fomento: Bolsas no Brasil - Doutorado