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A preliminary study of bipolar disorder type I by mass spectrometry-based serum lipidomics

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Ribeiro, Henrique C. [1] ; Klassen, Aline [2] ; Pedrini, Mariana [3] ; Carvalho, Michelle S. [4] ; Rizzo, Lucas B. [3] ; Noto, Mariane N. [3] ; Zeni-Graiff, Maiara [3] ; Sethi, Sumit [3] ; Fonseca, Francisco A. H. [5] ; Tasic, Ljubica [6] ; Hayashi, Mirian A. F. [4] ; Cordeiro, Quirino [7] ; Brietzke, Elisa [3] ; Sussulini, Alessandra [1]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Lab Bioanalyt & Integrated Omics LaBIOm, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Chem, Diadema, SP - Brazil
[3] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Res Grp Behav & Mol Neurosci Bipolar Disorder, Sao Paulo, SP - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, SP - Brazil
[5] Fed Univ Sao Paulo UNIFESP, Dept Med, Cardiol Div, Sao Paulo, SP - Brazil
[6] Univ Campinas UNICAMP, Inst Chem, Dept Organ Chem, Chem Biol Lab, POB 6154, BR-13083970 Campinas, SP - Brazil
[7] Santa Casa Sao Paulo, Sch Med Sci, Dept Psychiat, Sao Paulo, SP - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: PSYCHIATRY RESEARCH; v. 258, p. 268-273, DEC 2017.
Citações Web of Science: 8

The present study aimed at investigating possible alterations in the serum lipid profile of euthymic patients with bipolar disorder type I (BD) compared to healthy controls (HC). Thirty-five individuals from both genders were recruited, with 14 diagnosed and treated as BD patients (BD group) and 21 healthy subjects (HC group). Clinical assessment was based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Young Mania Rating Scale (YMRS), and 17-items of Hamilton Depression Rating Scale (HDRS-17) data, which were used to confirm diagnosis, to verify psychiatric comorbidities, and to estimate the severity of manic and depressive symptoms. Ultra-high performance liquid chromatography (UHPLC) coupled to high resolution mass spectrometry (HRMS) was applied to analyze the lipids extracted from all serum samples from both studied groups. In this pioneer and exploratory study, we observed different serum lipid profiles for BD and HC groups, especially regarding glycerophospholipid, glycerolipid, and sphingolipid distribution. Multivariate statistical analyses indicated that 121 lipids were significantly different between BD and HC. Phosphatidylinositols were identified as the most altered lipids in BD patient sera. The results of this preliminary study reinforce the role of lipid abnormalities in BD and offer additional methodological possibilities for investigation in the field. (AU)

Processo FAPESP: 14/18938-8 - Ressonância magnética nuclear aplicada em análises metabolômicas de pacientes e em modelos animais para os transtornos mentais graves
Beneficiário:Ljubica Tasic
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/13229-1 - Investigação de potenciais biomarcadores do transtorno bipolar usando a estratégia lipidômica
Beneficiário:Alessandra Sussulini
Linha de fomento: Auxílio à Pesquisa - Regular