The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis

Autor(es)

Damas, Felipe ^{[1, 2]} ; Libardi, Cleiton A. ^[2] ; Ugrinowitsch, Carlos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Ave Prof Mello Moraes 65, BR-05508030 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Phys Educ, Lab Neuromuscular Adaptat Resistance Training MUS, Rod Washington Luiz, Km 235-SP310, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. 118, n. 3, p. 485-500, MAR 2018.
• Citações Web of Science: 20

Resumo

Resistance training (RT)-induced skeletal muscle hypertrophy is a highly intricate process. Despite substantial advances, we are far from understanding exactly how muscle hypertrophy develops during RT. The aim of the present review is to discuss new insights related to the role of skeletal muscle damage and muscle protein synthesis (MPS) in mediating RT-induced hypertrophy. Specifically, the thesis that in the early phase of RT (<= 4 previous RT sessions) increases in muscle cross-sectional area are mostly attributable to muscle damage-induced muscle swelling; then (after similar to 10 sessions), a modest magnitude of muscle hypertrophy ensues; but only during a latter phase of RT (after similar to 18 sessions) is true muscle hypertrophy observed. We argue that the initial increases in MPS post-RT are likely directed to muscle repair and remodelling due to damage, and do not correlate with eventual muscle hypertrophy induced by several RT weeks. Increases in MPS post-RT session only contribute to muscle hypertrophy after a progressive attenuation of muscle damage, and even more significantly when damage is minimal. Furthermore, RT protocols that do not promote significant muscle damage still induce similar muscle hypertrophy and strength gains compared to conditions that do promote initial muscle damage. Thus, we conclude that muscle damage is not the process that mediates or potentiates RT-induced muscle hypertrophy. (AU)

• Processo FAPESP: 13/21218-4 - O papel da magnitude de dano muscular nas respostas hipertróficas
• Beneficiário: Cleiton Augusto Libardi
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/24259-1 - Individualidade biológica humana versus variáveis do treinamento de força: o que realmente importa para a hipertrofia muscular?
• Beneficiário: Felipe Romano Damas Nogueira
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/19594-0 - O papel do dano muscular na modulação da síntese protéica muscular
• Beneficiário: Felipe Romano Damas Nogueira
• Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 12/24499-1 - O papel da magnitude de dano muscular nas respostas hipertróficas
• Beneficiário: Felipe Romano Damas Nogueira
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/04299-1 - Individualidade biológica humana versus variáveis do treinamento de força: o que realmente importa para a hipertrofia muscular?
• Beneficiário: Cleiton Augusto Libardi
• Linha de fomento: Auxílio à Pesquisa - Regular