Modeling of non-Fickian diffusion and dissolution from a thin polymeric coating: An application to drug-eluting stents

Autor(es)

Gudino, E. ^[1] ; Oishi, C. M. ^[2] ; Sequeira, A. ^{[3, 4]}

Afiliação do(s) autor(es)

^[1] Univ Fed Parana, Dept Math, Rua Evaristo F F da Costa 408, BR-81530015 Curitiba, Parana - Brazil

^[2] Univ Estadual Paulista UNESP, Dept Math & Comp Sci, Fac Ciencias & Tecnol, Presidente Prudente - Brazil

^[3] Univ Lisbon, Inst Super Tecn, Dept Math, Lisbon - Portugal

^[4] Univ Lisbon, Inst Super Tecn, CEMAT IST, Lisbon - Portugal

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING; v. 114, n. 3, p. 292-320, APR 20 2018.
• Citações Web of Science: 3

Resumo

In this paper, we present a general model for non-Fickian diffusion and drug dissolution from a controlled drug delivery device coated with a thin polymeric layer. First, we study the stability and deduce an analytic solution to the problem. Then, we consider this solution and provide suitable boundary conditions to replace the problem of mass transport in the coating of a coronary drug-eluting stent. With this approach, we reduced the computational cost of performing numerical simulations in complex 3-dimensional geometries. The model for mass transport by a coronary drug-eluting stent is coupled with a non-Newtonian blood model flow. In order to show the effectiveness of the method, numerical experiments and a model validation with experimental data are also included. In particular, we investigate the influence of the non-Newtonian flow regime on the drug deposition in the arterial wall. (AU)

• Processo FAPESP: 13/07375-0 - CeMEAI - Centro de Ciências Matemáticas Aplicadas à Indústria
• Beneficiário: José Alberto Cuminato
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs